公开(公告)号：US20240150308A1

公开(公告)日：2024-05-09

申请号：US18532307

申请日：2023-12-07

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： CHUN-YU LIN ,  TZYH-MANN WEI ,  SHIH-YI WEI

IPC: C07D307/93 ,  C07C45/65 ,  C07C49/573 ,  C07C67/24 ,  C07C67/317 ,  C07C69/157 ,  C07C69/734 ,  C07D307/42 ,  C07F7/18 ,  C12P7/38

CPC classification number: C07D307/93 ,  C07C45/65 ,  C07C49/573 ,  C07C67/24 ,  C07C67/317 ,  C07C69/157 ,  C07C69/734 ,  C07D307/42 ,  C07F7/1892 ,  C12P7/38 ,  C07C2601/08 ,  C07C2601/10 ,  C07C2601/16

Abstract: The invention relates to processes for preparing benzoprostacyclin analogues and intermediates prepared from the process, and the benzoprostacyclin analogues prepared therefrom. The invention also relates to cyclopentenone intermediates in racemic or optically active form.

公开(公告)号：US11339110B2

公开(公告)日：2022-05-24

申请号：US16720711

申请日：2019-12-19

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Jian-Bang Jheng ,  Ming-Kun Hsu ,  Min-Kuan Hsu ,  Tzyh-Mann Wei

IPC: C07C59/72 ,  C07C51/43

Abstract: There is provided a crystalline Form I of anhydrous Treprostinil and processes for the preparation thereof. The crystalline Form I of anhydrous Treprostnil is a stable crystalline form, which can provide steady physicochemical properties for pharmaceutical formulations, and is advantageous widely and safety used in storage, shipment, and handling for commercially considerations.

公开(公告)号：US11332433B2

公开(公告)日：2022-05-17

申请号：US16938238

申请日：2020-07-24

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Ming-Kun Hsu ,  Tzyh-Mann Wei

IPC: C07C201/02 ,  C07C203/04 ,  C07C69/732 ,  C07F7/02 ,  A61K31/216

Abstract: Processes for preparing latanoprostene bunod and an intermediate prepared from the process. Also latanoprostene bunod compositions having high-purity latanoprostene bunod.

公开(公告)号：US10822321B2

公开(公告)日：2020-11-03

申请号：US15970067

申请日：2018-05-03

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Yu-Chih Yeh ,  Min-Kuan Hsu ,  Li-Ta Kao

IPC: C07D313/00 ,  C07D309/12 ,  C07C51/347 ,  C07F7/18 ,  C07D407/12 ,  C07C405/00 ,  C07C59/72 ,  C07C67/10 ,  C07C231/02 ,  C07D407/14 ,  C07C69/608 ,  C07C69/618

Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.

公开(公告)号：US10577340B1

公开(公告)日：2020-03-03

申请号：US16199443

申请日：2018-11-26

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Jian-Bang Jheng

IPC: C07D307/79

Abstract: The present invention provides crystalline Forms II and III of Beraprost-314d, and processes for the preparation thereof.

公开(公告)号：US10457623B1

公开(公告)日：2019-10-29

申请号：US16034598

申请日：2018-07-13

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Min-Kuan Hsu

IPC: C07C51/373 ,  C07F7/08 ,  C07C31/40 ,  C07D307/06

Abstract: The present invention relates to a novel process for preparing Lubiprostone and novel intermediates prepared from the process. The process of the present invention does not generate hydrogenated by-products that are difficult to be removed, and thus enables the production of Lubiprostone in an efficient and economical way.

公开(公告)号：US12221411B2

公开(公告)日：2025-02-11

申请号：US18325214

申请日：2023-05-30

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Chun-Yu Lin ,  Tzyh-Mann Wei ,  Shih-Yi Wei

IPC: C07C33/12 ,  C07C49/743 ,  C07C59/62 ,  C07D307/42 ,  C12P7/38 ,  C12P7/62

Abstract: The invention relates to processes for preparing carbaprostacyclin analogues and intermediates prepared from the processes. The invention also relates to cyclopentenone intermediates in racemic or optically active form.

公开(公告)号：US11447440B2

公开(公告)日：2022-09-20

申请号：US17083673

申请日：2020-10-29

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Jian-Bang Jheng ,  Chun Hsieh

IPC: C07C59/13 ,  C07C51/43 ,  C07C51/47

Abstract: Novel crystalline forms of Treprostinil monohydrate, a mixture including the same, and preparation methods thereof.

公开(公告)号：US10577341B1

公开(公告)日：2020-03-03

申请号：US16199471

申请日：2018-11-26

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Jian-Bang Jheng

IPC: C07D307/93

Abstract: The present invention provides a monohydrated form of Beraprost-314d, and a novel crystalline form of Beraprost-314d monohydrate, and processes for the preparation thereof.

公开(公告)号：US10253011B1

公开(公告)日：2019-04-09

申请号：US16034686

申请日：2018-07-13

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Jian-Bang Jheng

IPC: B01D9/00 ,  C07D311/94

Abstract: This present invention relates to novel Lubiprostone crystals and methods for preparing the same. The preparation methods provided by the invention can effectively reduce or eliminate impurity in the obtained Lubiprostone crystals.