公开(公告)号：US11485790B2

公开(公告)日：2022-11-01

申请号：US15302439

申请日：2015-04-07

申请人： Chugai Seiyaku Kabushiki Kaisha

发明人： Tomoyuki Igawa ,  Taro Miyazaki ,  Kenji Taniguchi ,  Naoka Hironiwa

IPC分类号： C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  C07K16/46 ,  A61K39/00

摘要： It was discovered that the use of an antigen-binding molecule having a cancer-specific antigen-binding domain, and a TNF superfamily-binding domain or a TNF receptor superfamily-binding domain enables agonist activity against a factor belonging to the TNF superfamily or the TNF receptor superfamily to be exhibited only in the presence of cancer-specific antigen-expressing cells, thus leading to activation of immune cells and thereby maintain anti-tumor activity while avoiding side effects such as hepatotoxicity. It was also discovered that concomitant use of the antigen-binding molecule with an antigen-binding molecule having a cancer-specific antigen-binding domain and a T cell receptor complex-binding domain can avoid side effects while increasing the anti-tumor activity.

公开(公告)号：US11660340B2

公开(公告)日：2023-05-30

申请号：US15776587

申请日：2016-11-17

申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人： Toshiaki Tsunenari ,  Yutaka Matsuda ,  Taro Miyazaki ,  Kenji Taniguchi

IPC分类号： A61P35/00 ,  A61K39/395 ,  A61K45/00 ,  A61K31/7068 ,  A61K33/243 ,  A61K39/00

CPC分类号： A61K39/39558 ,  A61K31/7068 ,  A61K33/243 ,  A61K39/395 ,  A61K45/00 ,  A61P35/00 ,  A61K2039/505 ,  A61K2039/507

摘要： The present invention provides methods for treating or preventing cancer by administering an anticancer agent and an antigen-binding molecule comprising a domain that binds to a molecule expressed on the surface of a cell having an immune response-suppressing function and a T cell receptor complex-binding domain. The present invention also provides pharmaceutical compositions for treating or preventing cancer, each comprising a combination of the anticancer agent and the antigen-binding molecule.

公开(公告)号：US20230151112A1

公开(公告)日：2023-05-18

申请号：US17933879

申请日：2022-09-21

申请人： Chugai Seiyaku Kabushiki Kaisha

发明人： Tomoyuki IGAWA ,  Taro Miyazaki ,  Kenji Taniguchi ,  Naoka Hironiwa

IPC分类号： C07K16/30 ,  A61K39/395 ,  C07K16/28 ,  C07K16/46

CPC分类号： C07K16/30 ,  C07K16/303 ,  A61K39/39558 ,  C07K16/2809 ,  C07K16/2878 ,  C07K16/3023 ,  C07K16/3038 ,  C07K16/3046 ,  C07K16/3061 ,  C07K16/468 ,  A61K2039/505

摘要： It was discovered that the use of an antigen-binding molecule having a cancer-specific antigen-binding domain, and a TNF superfamily-binding domain or a TNF receptor superfamily-binding domain enables agonist activity against a factor belonging to the TNF superfamily or the TNF receptor superfamily to be exhibited only in the presence of cancer-specific antigen-expressing cells, thus leading to activation of immune cells and thereby maintain anti-tumor activity while avoiding side effects such as hepatotoxicity. It was also discovered that concomitant use of the antigen-binding molecule with an antigen-binding molecule having a cancer-specific antigen-binding domain and a T cell receptor complex-binding domain can avoid side effects while increasing the anti-tumor activity.