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公开(公告)号：US11072666B2
公开(公告)日：2021-07-27
申请号：US16083975
申请日：2017-02-24
发明人： Yasuko Kinoshita , Yumiko Kawai , Toshiaki Tsunenari , Takahiro Ishiguro , Mika Endo , Yuji Sano
摘要： The present invention provides anticancer agents comprising as an active ingredient a bispecific antibody that comprises a domain comprising a glypican 3-binding antibody variable region, a domain comprising a T cell receptor complex-binding antibody variable region, and common L chains that can enhance the affinity for the two antigens, as well as pharmaceutical compositions comprising the bispecific antibody as an active ingredient, the compositions being for use in combination with other anticancer agents. The bispecific antibodies are novel molecules which are produced with high efficiency and have strong anti-tumor activity as well as safety and excellent pharmacodynamics. The bispecific antibodies can be expected to be applied to various cancers.
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公开(公告)号：US11660340B2
公开(公告)日：2023-05-30
申请号：US15776587
申请日：2016-11-17
IPC分类号： A61P35/00 , A61K39/395 , A61K45/00 , A61K31/7068 , A61K33/243 , A61K39/00
CPC分类号： A61K39/39558 , A61K31/7068 , A61K33/243 , A61K39/395 , A61K45/00 , A61P35/00 , A61K2039/505 , A61K2039/507
摘要： The present invention provides methods for treating or preventing cancer by administering an anticancer agent and an antigen-binding molecule comprising a domain that binds to a molecule expressed on the surface of a cell having an immune response-suppressing function and a T cell receptor complex-binding domain. The present invention also provides pharmaceutical compositions for treating or preventing cancer, each comprising a combination of the anticancer agent and the antigen-binding molecule.
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