公开(公告)号：US20170333416A1

公开(公告)日：2017-11-23

申请号：US15673073

申请日：2017-08-09

Applicant: CLEARSIDE BIOMEDICAL, INC.

Inventor： Vladimir ZARNITSYN ,  Samirkumar PATEL ,  Daniel WHITE ,  Glenn NORONHA ,  Brian BURKE

IPC: A61K31/4439 ,  A61K47/38 ,  A61K9/00 ,  A61K9/10 ,  A61K31/573 ,  A61M37/00 ,  A61K47/26 ,  A61K47/12 ,  A61K45/06 ,  C07K16/22 ,  A61K9/16 ,  A61K39/00

CPC classification number: A61K31/4439 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/10 ,  A61K9/16 ,  A61K31/573 ,  A61K45/06 ,  A61K47/12 ,  A61K47/26 ,  A61K47/38 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2300/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0061 ,  C07K16/22

Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

公开(公告)号：US20180325884A1

公开(公告)日：2018-11-15

申请号：US16041067

申请日：2018-07-20

Applicant: CLEARSIDE BIOMEDICAL, INC.

Inventor： Vladimir ZARNITSYN ,  Samirkumar PATEL ,  Daniel WHITE ,  Glenn NORONHA ,  Brian BURKE

IPC: A61K31/4439 ,  C07K16/22 ,  A61K47/38 ,  A61K9/00 ,  A61K9/10 ,  A61K9/16 ,  A61K31/573 ,  A61M37/00 ,  A61K47/26 ,  A61K47/12 ,  A61K45/06 ,  A61K39/00

CPC classification number: A61K31/4439 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/10 ,  A61K9/16 ,  A61K31/573 ,  A61K45/06 ,  A61K47/12 ,  A61K47/26 ,  A61K47/38 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2300/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0061 ,  C07K16/22

Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

公开(公告)号：US20160206628A1

公开(公告)日：2016-07-21

申请号：US15001610

申请日：2016-01-20

Applicant: Clearside Biomedical, Inc.

Inventor： Vladimir ZARNITSYN ,  Samirkumar PATEL ,  Daniel WHITE ,  Glenn NORONHA ,  Brian BURKE

IPC: A61K31/573 ,  A61K47/12 ,  A61K47/26 ,  A61K9/00 ,  A61K47/38

CPC classification number: A61K31/4439 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/10 ,  A61K9/16 ,  A61K31/573 ,  A61K45/06 ,  A61K47/12 ,  A61K47/26 ,  A61K47/38 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2300/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0061 ,  C07K16/22

Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

公开(公告)号：US20180028516A1

公开(公告)日：2018-02-01

申请号：US15454636

申请日：2017-03-09

Applicant: CLEARSIDE BIOMEDICAL, INC.

Inventor： Vladimir ZARNITSYN ,  Samirkumar PATEL ,  Daniel WHITE ,  Glenn NORONHA ,  Brian BURKE

IPC: A61K31/4439 ,  A61K47/26 ,  A61K9/00 ,  A61K9/10 ,  A61M37/00 ,  A61K47/38 ,  A61K47/12 ,  A61K45/06 ,  A61K31/573 ,  C07K16/22 ,  A61K9/16 ,  A61K39/00

CPC classification number: A61K31/4439 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/10 ,  A61K9/16 ,  A61K31/573 ,  A61K45/06 ,  A61K47/12 ,  A61K47/26 ,  A61K47/38 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2300/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0061 ,  C07K16/22

Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

公开(公告)号：US20220211618A1

公开(公告)日：2022-07-07

申请号：US17603816

申请日：2020-04-16

Applicant: CLEARSIDE BIOMEDICAL, INC.

Inventor： Thai Q. NGUYEN ,  Brian BURKE ,  Edward LEE ,  Rafael Victor ANDINO

IPC: A61K9/10 ,  A61K31/58 ,  A61K47/26 ,  A61K47/38 ,  A61K47/02 ,  A61K9/00 ,  A61M5/32

Abstract: The present disclosure relates to pharmaceutical suspensions of triamcinolone acetonide, methods of producing such suspensions and methods of using of such suspensions. The pharmaceutical suspensions of the present disclosure are stable and suitable for administration by suprachoroidal injection through a 30-gauge microneedle.

公开(公告)号：US20190240208A1

公开(公告)日：2019-08-08

申请号：US16124407

申请日：2018-09-07

Applicant: CLEARSIDE BIOMEDICAL, INC.

Inventor： Vladimir ZARNITSYN ,  Samirkumar PATEL ,  Daniel WHITE ,  Glenn NORONHA ,  Brian BURKE

IPC: A61K31/4439 ,  A61K47/26 ,  A61K9/00 ,  A61K9/10 ,  A61K47/38 ,  A61K45/06 ,  A61K47/12 ,  A61M37/00 ,  A61K9/16 ,  C07K16/22 ,  A61K31/573

CPC classification number: A61K31/4439 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/10 ,  A61K9/16 ,  A61K31/573 ,  A61K45/06 ,  A61K47/12 ,  A61K47/26 ,  A61K47/38 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2300/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0061 ,  C07K16/22

Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

公开(公告)号：US20210260047A1

公开(公告)日：2021-08-26

申请号：US17314272

申请日：2021-05-07

Applicant: CLEARSIDE BIOMEDICAL, INC.

Inventor： Vladimir ZARNITSYN ,  Samirkumar PATEL ,  Daniel WHITE ,  Glenn NORONHA ,  Brian BURKE

IPC: A61K31/4439 ,  A61K9/00 ,  A61K9/10 ,  A61K47/38 ,  A61K45/06 ,  C07K16/22 ,  A61K31/573 ,  A61K9/16 ,  A61M37/00 ,  A61K47/12 ,  A61K47/26

Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

公开(公告)号：US20160213662A1

公开(公告)日：2016-07-28

申请号：US15086485

申请日：2016-03-31

Applicant: Clearside Biomedical, Inc.

Inventor： Vladimir ZARNITSYN ,  Samirkumar PATEL ,  Daniel WHITE ,  Glenn NORONHA ,  Brian BURKE

IPC: A61K31/4439 ,  A61K9/16 ,  A61K9/00

CPC classification number: A61K31/4439 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/10 ,  A61K9/16 ,  A61K31/573 ,  A61K45/06 ,  A61K47/12 ,  A61K47/26 ,  A61K47/38 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2300/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0061 ,  C07K16/22

Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.