-
公开(公告)号:US20200030143A1
公开(公告)日:2020-01-30
申请号:US16591067
申请日:2019-10-02
Applicant: CLEARSIDE BIOMEDICAL, INC.
Inventor: Rafael Victor ANDINO , Vladimir ZARNITSYN , Jesse YOO , Christopher John BROOKS , Trent John KAHUTE , Justin William ARSENAULT , David Jackson TRETTIN , Andrew Kent BAUER , Stephanie Elaine LEWIS
IPC: A61F9/00 , A61J1/20 , A61M5/34 , A61M5/31 , A61M37/00 , A61M5/20 , A61M5/32 , A61M5/48 , A61M5/46
Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.
-
公开(公告)号:US20180028358A1
公开(公告)日:2018-02-01
申请号:US15714441
申请日:2017-09-25
Applicant: Clearside Biomedical, Inc.
Inventor: Rafael Victor ANDINO , Vladimir ZARNITSYN , Jesse YOO , Christopher John BROOKS , Trent John KAHUTE , Justin William ARSENAULT , David Jackson TRETTIN , Andrew Kent BAUER , Stephanie Elaine LEWIS
CPC classification number: A61F9/0017 , A61F2250/0007 , A61F2250/0069 , A61J1/201 , A61J1/2055 , A61J1/2096 , A61M5/2033 , A61M5/2053 , A61M5/31 , A61M5/3293 , A61M5/34 , A61M5/344 , A61M5/346 , A61M5/347 , A61M5/348 , A61M5/349 , A61M5/46 , A61M5/482 , A61M37/0015 , A61M2005/31508 , A61M2037/0023 , A61M2037/0061 , A61M2210/0612
Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.
-
3.
公开(公告)号:US20170095369A1
公开(公告)日:2017-04-06
申请号:US15383582
申请日:2016-12-19
Applicant: Clearside Biomedical, Inc.
CPC classification number: A61F9/0008 , A61M5/3286 , A61M5/329 , A61M5/3293 , A61M5/46 , A61M37/0015 , A61M2037/0023 , A61M2210/0612
Abstract: An apparatus includes a microneedle that defines a lumen therethrough. The microneedle has a proximal end portion a distal end portion and a hub portion between the proximal end portion and the distal end portion. The proximal end portion is configured to be coupled to a medicament container, such as, for example a syringe. The portion of the lumen within the proximal end portion has a first diameter. The distal end portion is configured to pierce a target tissue. The portion of the lumen within the distal end portion has a second diameter smaller than the first diameter. The hub portion includes a surface configured to contact the target tissue when the distal end portion is disposed with the target tissue.
-
公开(公告)号:US20250152413A1
公开(公告)日:2025-05-15
申请号:US19020585
申请日:2025-01-14
Applicant: Clearside Biomedical, Inc.
Inventor: Rafael Victor ANDINO , Chen-Rei WAN , Trent KAHUTE , Bradford A. RANGE , Clay G. PRICKETT
Abstract: Embodiments described herein relate to systems and methods of delivering medicinal components to target regions of an eye of a subject and/or patient. In some aspects, an apparatus includes a housing; a medicament container configured to accommodate a medicinal component; a sensor configured to measure a physical property of a subject; and an injector coupled to the medicament container and configured to produce a stream of the medicinal component directed towards a region of the eye of the subject based on the measured physical property.
-
公开(公告)号:US20220280386A1
公开(公告)日:2022-09-08
申请号:US17683421
申请日:2022-03-01
Applicant: CLEARSIDE BIOMEDICAL, INC.
Inventor: Rafael Victor ANDINO , Shelley Eckert HANCOCK , Thomas Edward GODFREY , Cherry WAN
Abstract: Embodiments described herein relate to methods and apparatus for extracting a fluid from a container. In some aspects, an extraction member can comprise a first coupling portion configured to removably couple the extraction member to a medicament container containing a medicament, a puncture member defining a fluidic channel and configured to pierce the septum seal to establish fluidic communication between the medicament container and the medicament injector, and a seal disposed between the first coupling portion and the second coupling portion, and defining an opening through which the puncture member is disposed and extends therefrom towards the first coupling portion thereby defining a medicament collection area circumferentially surrounding a portion of the puncture member between the seal and a distal end of the puncture member.
-
6.
公开(公告)号:US20210220173A1
公开(公告)日:2021-07-22
申请号:US17223971
申请日:2021-04-06
Applicant: CLEARSIDE BIOMEDICAL, INC.
Inventor: Rafael Victor ANDINO , Shelley Eckert HANCOCK
Abstract: An apparatus includes a housing, an adjustment member, and a microneedle. The housing can be coupled to a medicament container, and includes a hub surface that can contact a target surface. The adjustment member is within the housing and separates an inner volume of the housing into a first chamber and a second chamber. The first chamber is fluidically coupled with the medicament container. The adjustment member, which is coupled to the microneedle, can transition between a first configuration and a second configuration. A proximal end portion of the microneedle is fluidically coupled to the first chamber such that a substance can be conveyed from the medicament container through the microneedle. A distal tip of the microneedle extends from the hub surface by a first distance when the adjustment member is in the first configuration, and by a second distance when the adjustment member is in the second configuration.
-
公开(公告)号:US20190290485A1
公开(公告)日:2019-09-26
申请号:US16440108
申请日:2019-06-13
Applicant: CLEARSIDE BIOMEDICAL, INC.
Inventor: Rafael Victor ANDINO , Thomas Edward GODFREY , Shelley Eckert HANCOCK , Samirkumar PATEL , Keleigh Jo STRUDTHOFF , Jesse YOO , Vladimir ZARNITSYN
Abstract: Devices, methods, and kits for ocular drug delivery are described herein. In some embodiments, a method includes inserting a distal end portion of a puncture member into an eye to define a delivery passageway within the eye. The delivery passageway extends through ha sclera of the eye and a choroid of the eye. The delivery passageway is less than about 1.5 mm. The method further includes conveying a substance into a subretinal space within the eye via the distal end portion of the puncture member.
-
公开(公告)号:US20170112665A1
公开(公告)日:2017-04-27
申请号:US15399239
申请日:2017-01-05
Applicant: Clearside Biomedical, Inc.
Inventor: Rafael Victor ANDINO , Vladimir ZARNITSYN , Jesse YOO , Christopher John BROOKS , Trent John KAHUTE , Justin William ARSENAULT , David Jackson TRETTIN , Andrew Kent BAUER , Stephanie Elaine LEWIS
CPC classification number: A61F9/0017 , A61F2250/0007 , A61F2250/0069 , A61J1/201 , A61J1/2055 , A61J1/2096 , A61M5/2033 , A61M5/2053 , A61M5/31 , A61M5/3293 , A61M5/34 , A61M5/344 , A61M5/346 , A61M5/347 , A61M5/348 , A61M5/349 , A61M5/46 , A61M5/482 , A61M37/0015 , A61M2005/31508 , A61M2037/0023 , A61M2037/0061 , A61M2210/0612
Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.
-
公开(公告)号:US20230363941A1
公开(公告)日:2023-11-16
申请号:US18298332
申请日:2023-04-10
Applicant: Clearside Biomedical, Inc.
Inventor: Rafael Victor ANDINO , Chen-rei WAN , Clay G. PRICKETT , Jay HOPE , Jordan MYKLEBY , Nicolo GARBIN , Bradford A. RANGE , Justin D. HENRY
CPC classification number: A61F9/0017 , A61F9/00736
Abstract: Embodiments described herein relate to systems and methods of retinal injection. In some aspects, a method includes inserting a distal end portion of a hollow conduit of a medical injector into an eye of a patient until the distal end portion reaches a reference location, the medical injector having a housing from which the hollow conduit distally extends and confirming disposal of the distal end portion of the hollow conduit in the reference location. After the confirming, the method further includes extending the distal end portion of the hollow conduit distally relative to the housing and from the reference location such that the distal end portion enters an injection region of the eye. With the distal end portion of the hollow conduit disposed in the injection region of the eye, medicament is conveyed into the injection region via the hollow conduit.
-
公开(公告)号:US20220211618A1
公开(公告)日:2022-07-07
申请号:US17603816
申请日:2020-04-16
Applicant: CLEARSIDE BIOMEDICAL, INC.
Inventor: Thai Q. NGUYEN , Brian BURKE , Edward LEE , Rafael Victor ANDINO
Abstract: The present disclosure relates to pharmaceutical suspensions of triamcinolone acetonide, methods of producing such suspensions and methods of using of such suspensions. The pharmaceutical suspensions of the present disclosure are stable and suitable for administration by suprachoroidal injection through a 30-gauge microneedle.
-
-
-
-
-
-
-
-
-