公开(公告)号：US20190133933A1

公开(公告)日：2019-05-09

申请号：US16097303

申请日：2017-05-01

Applicant: CLEARSIDE BIOMEDICAL, INC.

Inventor： Richard BECKMAN ,  Jesse YOO ,  Rafael Victor ANDINO ,  Glenn NORONHA ,  Samirkumar PATEL ,  Donna TARABORELLI ,  Vladimir ZARNITSYN

IPC: A61K9/00 ,  A61K47/36 ,  A61F9/00 ,  A61F9/007 ,  A61M37/00

Abstract: The current disclosure relates to formulations and methods for reducing intraocular pressure (IOP) in the eye of a subject in need thereof. The disclosure also relates to formulations and methods for reducing intraocular pressure (IOP) related to glaucoma in a subject. The methods provided include non-surgically administering a non-pharmacologically active injectable formulation to the eye of the subject by using an apparatus that is suitable for delivering the formulations. The methods provided also include placing a solid implant into the eye of the subject to create a controlled space in the suprachoroidal space (SCS) or the supraciliary space of the eye of the subject in need thereof. The present disclosure further comprises facilitating and improving the aqueous outflows in the eye through the trabecular meshwork outflow pathway and/or uveoscleral outflow pathway and thereby decreasing the intraocular pressure.