公开(公告)号：US20200276131A1

公开(公告)日：2020-09-03

申请号：US16876812

申请日：2020-05-18

Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION

Inventor： Naren Vyavahare ,  Aditi Sinha

IPC: A61K9/51 ,  A61K39/44 ,  C07K16/18 ,  C07K16/28 ,  A61K47/69 ,  A61K47/68 ,  A61K47/02

Abstract: Methods and delivery agents for treatment of connective tissue that includes elastic fibers are described. Delivery agents are nano- or micro-sized particles that include a biologically active compound useful in treatment of degraded elastic fibers, and an anchoring agent at a surface that binds at or near the area of degraded elastic fibers. The delivery agents may be utilized for targeted delivery of biologically active compounds to degraded elastic fibers so as to maintain and/or regenerate the elastin component of connective tissue, and to prevent further degradation and/or rehabilitate the structural architecture of the connective tissue.

公开(公告)号：US11975109B2

公开(公告)日：2024-05-07

申请号：US16876812

申请日：2020-05-18

Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION

Inventor： Naren Vyavahare ,  Aditi Sinha

IPC: A61K39/395 ,  A61K9/51 ,  A61K39/44 ,  A61K47/02 ,  A61K47/68 ,  A61K47/69 ,  C07K16/18 ,  C07K16/28

CPC classification number: A61K9/5146 ,  A61K9/5153 ,  A61K39/44 ,  A61K47/02 ,  A61K47/6843 ,  A61K47/6937 ,  C07K16/18 ,  C07K16/2836

Abstract: Methods and delivery agents for treatment of connective tissue that includes elastic fibers are described. Delivery agents are nano- or micro-sized particles that include a biologically active compound useful in treatment of degraded elastic fibers, and an anchoring agent at a surface that binds at or near the area of degraded elastic fibers. The delivery agents may be utilized for targeted delivery of biologically active compounds to degraded elastic fibers so as to maintain and/or regenerate the elastin component of connective tissue, and to prevent further degradation and/or rehabilitate the structural architecture of the connective tissue.