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公开(公告)号:US20180318230A1
公开(公告)日:2018-11-08
申请号:US15766706
申请日:2016-10-07
发明人: Sunandini Chopra , Rohit Karnik , Amy Wang , Omid C. Farokhzad , Xue-Qing Zhang
CPC分类号: A61K9/5153 , A61K9/0019 , A61K9/5138 , A61K9/5146 , A61K38/28 , A61K47/6803 , A61K47/6933 , A61K47/6937 , A61P3/10 , A61P35/00 , Y02A50/401 , Y02A50/475 , Y02A50/481
摘要: Provided is a nanoparticle comprising a pH-responsive polymer, a pH-insensitive polymer and a payload molecule. The nanoparticle can act as a system for delivery of the payload that releases the payload in a pH sensitive manner.
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公开(公告)号:US20180256709A1
公开(公告)日:2018-09-13
申请号:US15889014
申请日:2018-02-05
发明人: Charles Zepp , Grayson B. Lipford , Yun Gao , Lloyd Johnston , Fen-ni Fu , Mark J. Keegan , Sam Baldwin
IPC分类号: A61K39/385 , C08J3/24 , A61K47/59 , A61K47/69 , A61K47/64 , A61K47/60 , A61K47/58 , C08G64/42 , C08G63/91 , C08G63/08 , C08G63/06 , C07D473/34 , C07D471/04 , B82Y5/00 , A61K39/39 , A61K39/00 , A61K9/51
CPC分类号: A61K39/385 , A61K9/5138 , A61K39/0013 , A61K39/39 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/64 , A61K47/6925 , A61K47/6935 , A61K47/6937 , A61K2039/55511 , A61K2039/55544 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/62 , A61K2039/627 , B82Y5/00 , C07D471/04 , C07D473/34 , C08G63/06 , C08G63/08 , C08G63/912 , C08G64/42 , C08J3/24 , C08J2367/04
摘要: This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.
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公开(公告)号:US20180243227A1
公开(公告)日:2018-08-30
申请号:US15558970
申请日:2016-03-17
发明人: Daniel A. HELLER , Ryan M. WILLIAMS
IPC分类号: A61K9/51 , A61K51/12 , A61P13/12 , A61K31/40 , A61K47/69 , A61K49/00 , A61K31/704 , A61K31/4412 , A61K31/404 , A61K31/4406 , A61K31/192 , A61K31/167 , A61K31/4709 , A61K31/519 , A61K31/4439 , A61K31/517 , A61K31/4985 , A61K31/277
CPC分类号: A61K9/5153 , A61K9/0019 , A61K9/5115 , A61K9/5123 , A61K9/5146 , A61K9/5169 , A61K31/167 , A61K31/192 , A61K31/277 , A61K31/40 , A61K31/404 , A61K31/4406 , A61K31/4412 , A61K31/4439 , A61K31/4709 , A61K31/4985 , A61K31/517 , A61K31/519 , A61K31/704 , A61K47/6937 , A61K49/0004 , A61K49/0032 , A61K49/0093 , A61K51/1244 , A61P13/12
摘要: A drug carrier nanoparticle has been synthesized that can specifically target the proximal tubules of the kidneys. The nanoparticles accumulate in the kidneys to a greater extent than other organs (e.g., up to 3 or more times greater in the kidney than any other organ). They can encapsulate many classes of drug molecules. The nanoparticles are biodegradable and release the drug as they degrade. The particles can sustainably release a drug within the kidneys for up to two months. The nanoparticles are useful for the treatment of diseases that affect the proximal tubules, such as heart failure, liver cirrhosis, hypertension, and renal failure; the study of relative blood flow to the renal cortex and medulla; and delivery of agents to treat gout.
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公开(公告)号:US20180221508A1
公开(公告)日:2018-08-09
申请号:US15749194
申请日:2016-07-29
发明人: Sudhakar KADIYALA , Donna T. WARD
IPC分类号: A61K47/68 , A61P35/00 , A61P37/04 , C07K16/28 , C07K16/46 , C07K16/24 , C07K16/22 , C07K16/30 , A61K41/00 , A61K47/69
CPC分类号: A61K47/6881 , A61K39/39 , A61K41/0042 , A61K47/6843 , A61K47/6845 , A61K47/6849 , A61K47/6851 , A61K47/6879 , A61K47/6883 , A61K47/6889 , A61K47/6933 , A61K47/6935 , A61K47/6937 , A61K2039/505 , A61K2039/55516 , A61P35/00 , A61P37/04 , C07K16/22 , C07K16/244 , C07K16/2818 , C07K16/2866 , C07K16/30 , C07K16/468 , C07K2317/31 , C07K2317/622 , C07K2317/75 , C07K2317/76 , C07K2319/30 , C12N2310/14 , C12N2310/16
摘要: The present invention relates to modulation of the tumor microenvironment to increase cancer specific immune responses. Conjugates, nanoparticles and formulations of the present invention relieve the inhibitory effect induced by tumor cells, and enhance antitumor immunity. The compostions provided herein can be used as immunotherapies, or as adjuvants used in conjunction with other immunotherapies such as peptide vaccines, cell vaccines and/or adoptive T cell transfer.
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公开(公告)号:US20180221499A1
公开(公告)日:2018-08-09
申请号:US15770513
申请日:2016-10-28
发明人: Richard Wooster , Kerry Whalen , Patrick Rosaire Bazinet , Mark T. Bilodeau , Sudhakar Kadiyala , Samantha Perino , Beata Sweryda-Krawiec , Rajesh R. Shinde
IPC分类号: A61K47/64 , A61P35/00 , A61K31/5365 , A61K31/506 , A61K45/06 , A61K51/08 , A61K31/7048 , A61K31/436 , A61K31/404 , A61K31/655 , A61K31/513 , A61K47/69
CPC分类号: A61K47/64 , A61K31/404 , A61K31/436 , A61K31/506 , A61K31/513 , A61K31/5365 , A61K31/655 , A61K31/7048 , A61K45/06 , A61K47/6937 , A61K51/083 , A61P35/00 , C07K14/72
摘要: Conjugates of an active agent such as DM1 attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker, and particles comprising such conjugates have been designed. Such conjugates and particles can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer.
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公开(公告)号:US09931410B2
公开(公告)日:2018-04-03
申请号:US14434300
申请日:2013-10-09
发明人: Pedro M. Valencia , Eric M. Pridgen , Suresh Gadde , Rohit Karnik , Robert S. Langer , Stephen J. Lippard , Omid C. Farokhzad
IPC分类号: A61K47/48 , A61K45/06 , A61K31/555 , A61K33/24 , A61K9/14 , A61K9/51 , A61K31/4745 , A61K47/34 , A61K47/59 , A61K47/68 , A61K47/69 , B82Y5/00
CPC分类号: A61K47/6937 , A61K9/14 , A61K9/51 , A61K9/5146 , A61K9/5153 , A61K31/4745 , A61K31/555 , A61K33/24 , A61K45/06 , A61K47/34 , A61K47/593 , A61K47/6869 , B82Y5/00 , A61K2300/00
摘要: Provided herein are compositions that contain a nanoparticle containing a plurality of polymers, wherein at least a fraction of the polymers comprise a hydrophobic polymer, a topoisomerase inhibitor, and a Pt-containing chemotherapeutic agent, where the polymers self-assemble in an aqueous liquid to form the nanoparticle, and where the Pt-containing chemotherapeutic agent and the topoisomerase inhibitor are present within the hydrophobic core of the nanoparticle in a ratio of between about 24:1 to about 1:24. Also provided are methods of reducing the proliferation of a cancer cell and methods of treating cancer in a subject that include the use of these compositions. Also provided are methods of making these nanoparticles.
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公开(公告)号:US09919059B2
公开(公告)日:2018-03-20
申请号:US14102118
申请日:2013-12-10
发明人: Cliff R. Wong , Moungi G. Bawendi , Dai Fukumura , Rakesh K. Jain
CPC分类号: A61K47/6937 , A61K47/50 , A61K47/55 , A61K47/56 , A61K47/62 , A61K47/64 , A61K47/641 , A61K47/65 , A61K47/6931
摘要: Nanoparticles for a selective, two stage delivery to tumors have been developed. The nanoparticles are initially sized so that they preferentially accumulate in the tumor tissue as a result of leakage through the defective vascular in the solid tumors. Once in the tumor tissue, the nanoparticles are cleaved hydrolytically and/or by enzymatic cleavage over time to release smaller nanoparticles carrying therapeutic, prophylactic or diagnostic agents into the necrotic interior of the tumors. This provides a simple, elegant and highly effective means of delivery drug selectively not just to tumors generally, but, more importantly, into the poorly vascularized necrotic interiors which drugs are normally unable to penetrate. The nanoparticles have a number of advantages: less toxicity due to selective accumulation only in the tumors; access into the poorly vascularized necrotic interiors of the tumor; and sustained release over a period of time within the tumor.
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公开(公告)号:US09884129B2
公开(公告)日:2018-02-06
申请号:US14589037
申请日:2015-01-05
IPC分类号: A01N63/00 , A61K47/48 , A61K38/18 , A61K31/573 , A61K31/704 , A61K35/28 , C12N5/0775 , A61K47/69
CPC分类号: A61K47/6937 , A61K31/573 , A61K31/704 , A61K35/28 , A61K38/1816 , A61K47/6921 , A61K47/6935 , C12N5/0662
摘要: A composition includes an isolated cell; at least one particle within said cell; and at least one active agent associated with the particle, wherein the active agent is capable of being released from the cell. A method includes administration of such a cell to a subject.
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公开(公告)号:US09884112B2
公开(公告)日:2018-02-06
申请号:US14658040
申请日:2015-03-13
发明人: Charles Zepp , Grayson B. Lipford , Yun Gao , Lloyd Johnston , Fen-ni Fu , Mark J. Keegan , Sam Baldwin
IPC分类号: A61K39/385 , C07D473/34 , C07D471/04 , C08J3/24 , A61K9/51 , B82Y5/00 , C08G63/08 , C08G63/91 , C08G64/42 , A61K39/39 , C08G63/06 , A61K47/60 , A61K47/58 , A61K47/59 , A61K47/64 , A61K47/69 , A61K39/00
CPC分类号: A61K39/385 , A61K9/5138 , A61K39/0013 , A61K39/39 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/64 , A61K47/6925 , A61K47/6935 , A61K47/6937 , A61K2039/55511 , A61K2039/55544 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/62 , A61K2039/627 , B82Y5/00 , C07D471/04 , C07D473/34 , C08G63/06 , C08G63/08 , C08G63/912 , C08G64/42 , C08J3/24 , C08J2367/04
摘要: This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.
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公开(公告)号:US09872913B2
公开(公告)日:2018-01-23
申请号:US15161785
申请日:2016-05-23
申请人: Pfizer Inc.
发明人: Greg Troiano , Michael Figa , Abhimanyu Sabnis
IPC分类号: A61K9/14 , A61K31/436 , A61K31/439 , A61K47/48 , A61K9/107 , A61K47/34 , A61K9/10 , A61K9/19 , A61K9/51 , A61K31/337 , A61K31/475 , B82Y5/00 , A61J3/00 , A61K31/4355 , A61K31/437 , A61K31/704 , A61K31/7068 , A61K47/69 , A61K9/16 , C07C59/08
CPC分类号: A61K47/34 , A61J3/00 , A61K9/10 , A61K9/107 , A61K9/1647 , A61K9/19 , A61K9/5146 , A61K9/5153 , A61K31/337 , A61K31/4355 , A61K31/436 , A61K31/437 , A61K31/439 , A61K31/475 , A61K31/704 , A61K31/7068 , A61K47/6915 , A61K47/6925 , A61K47/6937 , B82Y5/00 , C07C59/08 , Y10S977/773
摘要: The present disclosure generally relates to methods of making nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol.
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