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公开(公告)号：US11773362B2
公开(公告)日：2023-10-03
申请号：US17244447
申请日：2021-04-29
Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION
Inventor： Leslie Sierad , Christopher Delaney , Richard Pascal, III , Dan Simionescu , Agneta Simionescu
CPC classification number: C12M41/40 , C12M21/08 , C12M23/00 , C12M23/44 , C12M29/00 , C12M29/12 , C12M35/04
Abstract: Bioreactors and components of bioreactors are described as may be beneficially utilized in development and conditioning of cellular materials for study or implant. The bioreactors are modular, and components of the bioreactors can be easily assembled with alternatives provided to develop specific, predetermined conditioning environments for cellular materials (e.g., implantable tissue). By selection of one of multiple alternative compliance chambers, a bioreactor can be utilized to condition tissue in a low-pressure circuit (e.g., a pulmonary heart circuit), and by utilization of an alternative compliance chamber, the bioreactor can instead condition tissue in a high-pressure circuit (e.g., an aortic heart circuit).
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公开(公告)号：US20180296342A1
公开(公告)日：2018-10-18
申请号：US16010889
申请日：2018-06-18
Applicant: Clemson University Research Foundation
Inventor： Leslie Sierad , Richard Pascal, III , Chris deBorde , Dan Simionescu , Agneta Simionescu
IPC: A61F2/24
CPC classification number: A61F2/2472
Abstract: Tissue holders that can be used for gripping natural or synthetic heart valves are described. The tissue holder can include a clamping mechanism and a spring and can be self-adjusting with regard to pressure applied to the tissue gripped in the holder. The tissue holder can be removably attached to systems for processing the tissues and can provide completely hands-free processing of a tissue from development or excisement to implantation and/or completion of testing.
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公开(公告)号：US10660754B2
公开(公告)日：2020-05-26
申请号：US16010889
申请日：2018-06-18
Applicant: Clemson University Research Foundation
Inventor： Leslie Sierad , Richard Pascal, III , Chris deBorde , Dan Simionescu , Agneta Simionescu
IPC: A61F2/24
Abstract: Tissue holders that can be used for gripping natural or synthetic heart valves are described. The tissue holder can include a clamping mechanism and a spring and can be self-adjusting with regard to pressure applied to the tissue gripped in the holder. The tissue holder can be removably attached to systems for processing the tissues and can provide completely hands-free processing of a tissue from development or excisement to implantation and/or completion of testing.
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