公开(公告)号：US20220155302A1

公开(公告)日：2022-05-19

申请号：US17588925

申请日：2022-01-31

Applicant: CLEVELAND HEARTLAB, INC.

Inventor： Celalettin Topbas ,  Cory Bystrom

IPC: G01N33/573 ,  G01N1/28

Abstract: Provided herein are methods, systems, and compositions for Lp-PLA2 detection assays that employ amounts of detergent to liberate all or nearly all of the Lp-PLA2 molecules from associated lipoprotein particles. In this regard, the true Lp-PLA2 concentration can be detected in a sample, which correlates better with known Lp-PLA2 activity assays.

公开(公告)号：US11237167B2

公开(公告)日：2022-02-01

申请号：US15874078

申请日：2018-01-18

Applicant: Cleveland HeartLab, Inc.

Inventor： Celalettin Topbas ,  Cory Bystrom

IPC: G01N33/573 ,  G01N1/28

Abstract: Provided herein are methods, systems, and compositions for Lp-PLA2 detection assays that employ amounts of detergent to liberate all or nearly all of the Lp-PLA2 molecules from associated lipoprotein particles. In this regard, the true Lp-PLA2 concentration can be detected in a sample, which correlates better with known Lp-PLA2 activity assays.

公开(公告)号：US20180209977A1

公开(公告)日：2018-07-26

申请号：US15874078

申请日：2018-01-18

Applicant: Cleveland HeartLab, Inc.

Inventor： Celalettin Topbas ,  Cory Bystrom

IPC: G01N33/573

CPC classification number: G01N33/573 ,  G01N1/28 ,  G01N2333/92 ,  G01N2800/32

Abstract: Provided herein are methods, systems, and compositions for Lp-PLA2 detection assays that employ amounts of detergent to liberate all or nearly all of the Lp-PLA2 molecules from associated lipoprotein particles. In this regard, the true Lp-PLA2 concentration can be detected in a sample, which correlates better with known Lp-PLA2 activity assays.