公开(公告)号：US10918588B2

公开(公告)日：2021-02-16

申请号：US14441782

申请日：2013-11-08

Applicant: COLGATE-PALMOLIVE COMPANY ,  HOWARD UNIVERSITY

Inventor： Tongxin Wang ,  Yanda Lei ,  James W. Mitchell ,  Lynette Zaidel ,  Jian-hong Qiu ,  Mahmoud Hassan

IPC: C08F293/00 ,  A61Q11/02 ,  A61K8/90 ,  A61K6/00 ,  A61Q11/00 ,  A61K8/21

Abstract: Described herein are block copolymers having hydrophobic blocks and hydrophilic blocks which are effective in binding to the surface of hard tissue; compositions comprising the same, as well as methods of making and using the same.

公开(公告)号：US20140134116A1

公开(公告)日：2014-05-15

申请号：US14075230

申请日：2013-11-08

Applicant: Colgate-Palmolive Company ,  Howard University

Inventor： Tongxin Wang ,  Yanda Lei ,  James W. Mitchell ,  Lynette Zaidel ,  Jianhong Qiu ,  Mahmoud Hassan

IPC: A61K8/90 ,  A61Q11/00

CPC classification number: A61K8/90 ,  A61K8/21 ,  A61Q11/00 ,  C08F293/005

Abstract: Described herein are block copolymers having hydrophobic blocks and hydrophilic blocks which are effective in binding to the surface of hard tissue; compositions comprising the same, as well as methods of making and using the same are also described.

Abstract translation: 这里描述的是具有疏水性嵌段和亲水性嵌段的嵌段共聚物，该嵌段共聚物有效结合硬组织的表面; 还描述了包含它们的组合物，以及制备和使用它们的方法。

公开(公告)号：US11267950B2

公开(公告)日：2022-03-08

申请号：US16520762

申请日：2019-07-24

Applicant: HOWARD UNIVERSITY

Inventor： Tongxin Wang ,  James W. Mitchell

IPC: C08K3/32 ,  A61L27/12 ,  A61L27/18 ,  A61L27/58

Abstract: A method is provided for synthesizing PLA/apatite composites with improved mechanical strength. In one aspect, a calcium-phosphate/phosphonate hybrid shell is developed to incorporate more reactive hydroxyl groups onto hydroxyapatite (HA) particles. PLA is covalently bonded to HA calcium phosphate hybrid shell, creating a strong interphase between HA and PLA, thus significantly improve the mechanical strength in comparison to that of non-modified HA.