公开(公告)号：US20190070079A1

公开(公告)日：2019-03-07

申请号：US16082991

申请日：2017-03-06

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Anna TAMPIERI ,  Monica SANDRI ,  Simone SPRIO

IPC: A61K8/24 ,  A61K8/29 ,  A61K8/65 ,  A61K8/73 ,  A61K8/85 ,  A61K8/86 ,  A61K8/02 ,  A61Q17/04

Abstract: The present invention relates to a composition for the protection against solar radiation, consisting of an organic matrix, preferably a gelatin, and hydroxyapatite nanoparticles modified by the substitution of part of the phosphorus with titanium, and part of the calcium with iron.

公开(公告)号：US20200030566A1

公开(公告)日：2020-01-30

申请号：US16489504

申请日：2018-02-27

Applicant: Consiglio Nazionale Delle Ricerche

Inventor： Monica SANDRI ,  Anna TAMPIERI ,  Simone SPRIO

IPC: A61M16/10 ,  C08J3/075

Abstract: Filter made entirely with natural and biodegradable materials, for the protection of the respiratory tract of patients in the medical-surgical field and process for making it. The filter has a porosity or 80-98% and pore diameters of 100-350 micrometers and the pores have a shape of channels open at the ends, which are parallel to each other. The filter is obtained by preparing an aqueous solution of chitosan and an aqueous solution of gelatin, mixing them, pouring it into a container, keeping the container closed until obtaining a hydrogel and freeze-drying. A cross-linking step takes place by (a) adding a chemical cross-linker to the mixture of the chitosan and gelatine solutions and cross-linking before freeze-drying, or (b) subjecting the freeze-drying product to a thermal dehydration treatment.

公开(公告)号：US20170348245A1

公开(公告)日：2017-12-07

申请号：US15538663

申请日：2015-12-22

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE ,  ISTITUTO NAZIONALE ASSICURAZIONE CONTRO GLI INFORTUNI SUL LAVORO

Inventor： Daniele CATALUCCI ,  Michele MIRAGOLI ,  Michele IAFISCO ,  Anna TAMPIERI

IPC: A61K9/51 ,  A61K47/52 ,  A61K9/00 ,  A61K38/03 ,  A61K47/69 ,  A61K31/7105 ,  C12N15/113

Abstract: The invention relates to a process for the preparation of a product comprising one or more nanoparticles of calcium phosphate (CaP-NP) with negative surface charge having a ζ-potential in the range from −41.0 mV to −27.0 mV comprising the steps of: a) maintaining a mixture having a pH in the range from 7 to 10 and comprising an aqueous solution of calcium, an aqueous solution of phosphate and a solution of citrate ions at a temperature in the range from 20° C. to 40° C. for a time in the range from 30 seconds to 10 minutes; b) removing non-reacted ions from the solution of step a), thus obtaining a suspension of one or more nanoparticles of calcium phosphate (CaP-NP); c) recovering the product of one or more nanoparticles of calcium phosphate (CaP-NP) from the suspension of step b). In an advantageous embodiment, the process of the invention provides, in the mixture of step a), also an aqueous solution of one or more therapeutic/diagnostic compounds. The product of the invention may be used as a vehicle for one or more diagnostic/therapeutic compounds for the treatment of cardiovascular diseases through inhalation administration.