公开(公告)号：US10286085B2

公开(公告)日：2019-05-14

申请号：US14909854

申请日：2014-07-26

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Claudio Passananti ,  Nicoletta Corbi ,  Maria Grazia Di Certo ,  Elisabetta Mattei ,  Cinzia Pisani ,  Georgios Strimpakos

IPC: A61K48/00 ,  C07K14/47 ,  G01N33/68 ,  C07K14/005 ,  C12N15/86 ,  A61K38/00

Abstract: The present invention features recombinant adeno-associated vectors for delivery of genes to both skeletal and cardiac muscle and methods for treatment of muscle defects, including Duchenne's muscular dystrophy.

公开(公告)号：US10301367B2

公开(公告)日：2019-05-28

申请号：US15328833

申请日：2015-07-24

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Claudio Passananti ,  Nicoletta Corbi ,  Maria Grazia Di Certo ,  Elisabetta Mattei ,  Cinzia Pisani ,  Georgios Strimpakos ,  Siro Luvisetto

IPC: C07K14/47 ,  A61K38/17 ,  A61K48/00 ,  C12N15/62

Abstract: The present invention features modified human transcription factors capable of increasing utrophin expression, recombinant adeno-associated vectors for delivery of the modified human transcription factors, and methods of treating muscle diseases, including Duchenne's muscular dystrophy.