公开(公告)号：US10035801B2

公开(公告)日：2018-07-31

申请号：US14775405

申请日：2014-03-13

Applicant: CONSTELLATION PHARMACEUTICALS, INC. ,  GENENTECH, INC.

Inventor： Brian K. Albrecht ,  Steven F. Bellon ,  Victor S. Gehling ,  Jean-Christophe Harmange ,  Kwong Wah Lai ,  Jun Liang ,  Peter Dragovich ,  Daniel F. Ortwine ,  Sharada Labadie ,  Birong Zhang ,  James Richard Kiefer

IPC: C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  A61K31/5377 ,  A61K31/337 ,  A61K31/517 ,  A61K31/437 ,  C12N9/99 ,  C07D498/04 ,  C07D487/14

CPC classification number: C07D487/04 ,  A61K31/337 ,  A61K31/437 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61K45/06 ,  C07D487/14 ,  C07D498/04 ,  C12N9/99

Abstract: Provided are compounds useful as inhibitors of one or more histone demethylases, such as KDM5. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using the present composition in the treatment of various disorders.