公开(公告)号：US20150182527A1

公开(公告)日：2015-07-02

申请号：US14572057

申请日：2014-12-16

Applicant: COOK MEDICAL TECHNOLOGIES LLC

Inventor： Steven L. Pendleton ,  Will C. McRoy, JR.

IPC: A61K31/506 ,  A61L29/14 ,  A61L29/16 ,  A61K31/14 ,  A61K31/4196

CPC classification number: A61K31/506 ,  A61K31/14 ,  A61K31/4196 ,  A61L27/14 ,  A61L27/54 ,  A61L29/04 ,  A61L29/16 ,  A61L31/04 ,  A61L31/16 ,  A61L2300/208 ,  A61L2300/404 ,  A61M25/0017 ,  A61M27/008 ,  A61M2025/0056 ,  A61K2300/00

Abstract: One aspect provides a composition including a quaternary ammonium salt and an azole. The azole and the quaternary ammonium salt can be present in proportions providing a synergistic effect against a fungal organism. In one embodiment, the composition also includes a pharmaceutically acceptable carrier. Another aspect provides implantable medical devices containing a composition including a quaternary ammonium salt and an azole. In certain embodiments, the combination is present in an elutable form. Another aspect provides methods of treating a human or veterinary patient for an infection including administrating a composition including a quaternary ammonium salt and an azole.

Abstract translation: 一方面提供了包含季铵盐和唑的组合物。 唑和季铵盐可以按照提供对真菌生物体的协同作用的比例存在。 在一个实施方案中，组合物还包括药学上可接受的载体。 另一方面提供了含有包含季铵盐和唑的组合物的可植入医疗装置。 在某些实施方案中，组合以可洗涤形式存在。 另一方面提供了治疗人或兽医患者感染的方法，包括施用包含季铵盐和唑的组合物。