公开(公告)号：US20220332635A1

公开(公告)日：2022-10-20

申请号：US17631595

申请日：2020-07-07

Applicant: CORNING INCORPORATED

Inventor： Sinue Gomez-Mower ,  Yuhui Jin ,  Aize Li ,  Kelly Ann Murphy ,  Carlton Maurice Truesdale

IPC: C03C21/00

Abstract: The methods generally include contacting an alkali-containing glass article having a first alkali metal cation with a molten salt bath including from 0.1 wt. % to 3 wt. % nanoparticles and at least one alkali metal salt having a second alkali metal cation that has an atomic radius larger than an atomic radius of the first alkali metal cation. The nanoparticles may include at least one of metalloid oxide nanoparticles and metal oxide nanoparticles. The methods also include maintaining contact of the glass article with the molten salt bath to allow the first alkali metal cations to be exchanged with the second alkali metal cations of the molten salt bath. Further, the methods may include removing the glass article from contact with the molten salt bath to produce a strengthened glass article. A Surface Hydrolytic Resistance titration volume of the strengthened glass article may be less than 1.5 mL.

公开(公告)号：US20210080448A1

公开(公告)日：2021-03-18

申请号：US17104234

申请日：2020-11-25

Applicant: CORNING INCORPORATED

Inventor： Kelly Ann Murphy ,  Robert Anthony Schaut

IPC: G01N33/38 ,  G01N17/00 ,  A61J1/14 ,  G01N1/32 ,  C03C15/00

Abstract: A method of making a glass container for storing a pharmaceutical formulation includes heating a Type 1 glass composition according to ASTM Standard E438-92 (2011) to form a glass melt, and forming the glass melt into a glass tube. The glass tube is then re-formed into the glass container having a glass body with: a wall region with an interior surface and an exterior surface; a heel region; and a base region. The interior surface of the glass container is formed by the interior surface of the glass body. A glass pharmaceutical container has a CDR value of less than or equal to 6.0, at least a class A2 base resistance or better according to ISO 695, at least a type HGB2 hydrolytic resistance or better according to ISO 719, and Type 1 chemical durability according to USP .

公开(公告)号：US20180100846A1

公开(公告)日：2018-04-12

申请号：US15782707

申请日：2017-10-12

Applicant: CORNING INCORPORATED

Inventor： Kelly Ann Murphy ,  Robert Anthony Schaut

IPC: G01N33/38 ,  A61J1/14 ,  G01N17/00

CPC classification number: G01N33/386 ,  A61J1/1468 ,  C03C15/00 ,  G01N1/32 ,  G01N17/00

Abstract: A method including obtaining glass containers, and adding a solvent to 5.0% by volume to less than or equal to 50.0% by volume. Heating to an elevated temperature and cooling to room temperature. The solvent is consolidated and titrated, where an amount of a titrant is an as received titrant volume. Glass containers are etched, and a second solvent is added at 8.0% by volume to less than or equal to 25.0% by volume. The containers are heated to an elevated temperature and cooled to room temperature. The second solvent is consolidated and titrated, where an amount of a titrant is an etched titrant volume. The Chemical Durability Ratio (CDR) of the plurality of glass containers is calculated where: CDR = As   Received   Titrant   Volume Etched   Titrant   Volume .