公开(公告)号：US09790465B2

公开(公告)日：2017-10-17

申请号：US14087906

申请日：2013-11-22

Applicant: CORNING INCORPORATED

Inventor： Scott Matthew Bennett ,  Brian Robb Douglass ,  Paul Ernest Gagnon, Jr. ,  Gregory Roger Martin ,  Paul Michael Szlosek ,  Allison Jean Tanner

IPC: C12M3/00 ,  C12N5/071 ,  C12M1/00 ,  C12M1/32 ,  C12M1/04 ,  C12M1/12

CPC classification number: C12N5/0602 ,  C12M23/02 ,  C12M23/12 ,  C12M23/24 ,  C12M25/04 ,  C12M29/04

Abstract: A spheroid cell culture article including: a frame having a chamber including: an opaque side wall surface; a top aperture; a gas-permeable, transparent bottom; and optionally a chamber annex surface and second bottom, and at least a portion of the transparent bottom includes at least one concave arcuate surface, is disclosed. Methods of making and using the article are also disclosed.

公开(公告)号：US12146154B2

公开(公告)日：2024-11-19

申请号：US17005801

申请日：2020-08-28

Applicant: CORNING INCORPORATED

Inventor： Scott Matthew Bennett ,  Brian Robb Douglass ,  Paul Ernest Gagnon, Jr. ,  Gregory Roger Martin ,  Paul Michael Szlosek ,  Allison Jean Tanner

IPC: C12N5/071 ,  C12M1/00 ,  C12M1/04 ,  C12M1/12 ,  C12M1/32

Abstract: A spheroid cell culture article including: a chamber including: an opaque side wall surface; a top aperture; and a gas-permeable, liquid impermeable bottom including at least one concave surface, wherein at least a portion of the bottom is transparent, wherein at least a portion of the bottom includes a low-adhesion or no-adhesion material in or on the at least one concave surface, and wherein the gas permeable, liquid impermeable bottom includes polystyrene.

公开(公告)号：US20230365907A1

公开(公告)日：2023-11-16

申请号：US18030665

申请日：2021-10-07

Applicant: CORNING INCORPORATED

Inventor： Theresa Chang ,  Paula Jean Dolley-Sonneville ,  Paul Ernest Gagnon, Jr. ,  Vinalia Tjong ,  Yue Zhou

IPC: C12M1/00 ,  C12M1/12

CPC classification number: C12M23/20 ,  C12M25/14

Abstract: A cell culture substrate is provided that includes a substrate lattice having an ordered array of fibers and pores disposed between the fibers. The ordered array of fibers includes a cell culture surface to support adherent or semi-adherent cells during cell culture. The cell culture substrate further includes a positive charge coating disposed on the cell culture surface to promote adhesion of cells to the cell culture surface.

公开(公告)号：US11441121B2

公开(公告)日：2022-09-13

申请号：US15708473

申请日：2017-09-19

Applicant: CORNING INCORPORATED

Inventor： Scott Matthew Bennett ,  Brian Robb Douglass ,  Paul Ernest Gagnon, Jr. ,  Gregory Roger Martin ,  Paul Michael Szlosek ,  Allison Jean Tanner

IPC: C12N5/071 ,  C12M1/00 ,  C12M1/32 ,  C12M1/04 ,  C12M1/12

Abstract: A spheroid cell culture article including: a frame having a chamber including: an opaque side wall surface; a top aperture; a gas-permeable, transparent bottom; and optionally a chamber annex surface and second bottom, and at least a portion of the transparent bottom includes at least one concave arcuate surface, is disclosed. Methods of making and using the article are also disclosed.