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1.发明申请METHODS FOR PRODUCING SURFACES THAT RESIST NON-SPECIFIC PROTEIN BINDING AND CELL ATTACHMENT 审中-公开用于生产抗性非特异性蛋白质结合和细胞附着的表面的方法公开(公告)号：US20140162078A1
公开(公告)日：2014-06-12
申请号：US14178875
申请日：2014-02-12
申请人： Corning Incorporated
IPC分类号： G01N33/543 , B05D3/14
CPC分类号： G01N33/54393 , B05D3/14 , Y10T428/31 , Y10T428/31862 , Y10T428/31942
摘要： A method is disclosed herein for treating a polymeric surface to resist non-specific binding of biomolecules and attachment of cells. The method includes the steps of: imparting a charge to the polymeric surface to produce a charged surface; exposing the charged surface to a nitrogen-rich polymer to form a polymerized surface; exposing the polymerized surface to an oxidized polysaccharide to form an aldehyde surface; and exposing the aldehyde surface to a reducing agent. Advantageously, a method is provided which produces surfaces that resist non-specific protein binding and cell attachment and that avoids the use of photochemical reactions or prior art specially designed compounds.
摘要翻译： 本文公开了用于处理聚合物表面以抵抗生物分子的非特异性结合和细胞附着的方法。 该方法包括以下步骤：向聚合物表面施加电荷以产生带电表面; 将带电表面暴露于富氮聚合物以形成聚合表面; 将聚合的表面暴露于氧化多糖以形成醛表面; 并将醛表面暴露于还原剂。 有利地，提供了产生抵抗非特异性蛋白质结合和细胞附着并避免使用光化学反应或现有技术特别设计的化合物的表面的方法。
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2.发明申请METHODS FOR PRODUCING SURFACES THAT RESIST NON-SPECIFIC PROTEIN BINDING AND CELL ATTACHMENT 有权用于生产抗性非特异性蛋白质结合和细胞附着的表面的方法公开(公告)号：US20130288065A1
公开(公告)日：2013-10-31
申请号：US13927820
申请日：2013-06-26
申请人： Corning Incorporated
IPC分类号： G01N33/543 , B05D3/14
CPC分类号： G01N33/54393 , B05D3/14 , Y10T428/31 , Y10T428/31862 , Y10T428/31942
摘要： A method is disclosed herein for treating a polymeric surface to resist non-specific binding of biomolecules and attachment of cells. The method includes the steps of: imparting a charge to the polymeric surface to produce a charged surface; exposing the charged surface to a nitrogen-rich polymer to form a polymerized surface; exposing the polymerized surface to an oxidized polysaccharide to form an aldehyde surface; and exposing the aldehyde surface to a reducing agent. Advantageously, a method is provided which produces surfaces that resist non-specific protein binding and cell attachment and that avoids the use of photochemical reactions or prior art specially designed compounds.
摘要翻译： 本文公开了一种用于处理聚合物表面以抵抗生物分子的非特异性结合和细胞附着的方法。 该方法包括以下步骤：向聚合物表面施加电荷以产生带电表面; 将带电表面暴露于富氮聚合物以形成聚合表面; 将聚合的表面暴露于氧化多糖以形成醛表面; 并将醛表面暴露于还原剂。 有利地，提供了产生抵抗非特异性蛋白质结合和细胞附着并避免使用光化学反应或现有技术特别设计的化合物的表面的方法。
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公开(公告)号：US09999859B2
公开(公告)日：2018-06-19
申请号：US14613774
申请日：2015-02-04
申请人： CORNING INCORPORATED
IPC分类号： B01D69/14 , G01N15/08 , B01D71/50 , B01D71/34 , B01D71/82 , B01D71/74 , B01D67/00 , B01D69/10 , B01D61/38 , G01N1/40 , B01L3/00
CPC分类号： B01D69/144 , B01D61/38 , B01D67/0002 , B01D69/10 , B01D71/34 , B01D71/50 , B01D71/74 , B01D71/82 , B01D2323/04 , B01L3/50255 , G01N15/08 , G01N15/082 , G01N2001/4016 , G01N2015/084 , G01N2015/086 , Y10T436/255
摘要： With the subject invention, a method is provided for preparing a filter membrane including the steps of dispersing a liquid which is generally hydrophobic into the pores of a porous membrane, and applying a solution containing lipids onto at least a first surface of the porous membrane containing the liquid. Advantageously, the subject invention allows for filter membranes to be prepared which can be stored for periods of time without degradation in performance. The subject invention may have applicability in various contexts, but is well-suited for preparing filter membranes for permeability screening, particularly Parallel Artificial Membrane Permeability Assay (PAMPA).
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4.发明授权公开(公告)号：US09945849B2
公开(公告)日：2018-04-17
申请号：US14178875
申请日：2014-02-12
申请人： Corning Incorporated
IPC分类号： G01N33/543 , B05D3/14
CPC分类号： G01N33/54393 , B05D3/14 , Y10T428/31 , Y10T428/31862 , Y10T428/31942
摘要： A method is disclosed herein for treating a polymeric surface to resist non-specific binding of biomolecules and attachment of cells. The method includes the steps of: imparting a charge to the polymeric surface to produce a charged surface; exposing the charged surface to a nitrogen-rich polymer to form a polymerized surface; exposing the polymerized surface to an oxidized polysaccharide to form an aldehyde surface; and exposing the aldehyde surface to a reducing agent. Advantageously, a method is provided which produces surfaces that resist non-specific protein binding and cell attachment and that avoids the use of photochemical reactions or prior art specially designed compounds.
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5.发明授权Methods for producing surfaces that resist non-specific protein binding and cell attachment 有权用于产生抗非特异性蛋白质结合和细胞附着的表面的方法公开(公告)号：US08652584B2
公开(公告)日：2014-02-18
申请号：US13927820
申请日：2013-06-26
申请人： Corning Incorporated
CPC分类号： G01N33/54393 , B05D3/14 , Y10T428/31 , Y10T428/31862 , Y10T428/31942
摘要： A method is disclosed herein for treating a polymeric surface to resist non-specific binding of biomolecules and attachment of cells. The method includes the steps of: imparting a charge to the polymeric surface to produce a charged surface; exposing the charged surface to a nitrogen-rich polymer to form a polymerized surface; exposing the polymerized surface to an oxidized polysaccharide to form an aldehyde surface; and exposing the aldehyde surface to a reducing agent. Advantageously, a method is provided which produces surfaces that resist non-specific protein binding and cell attachment and that avoids the use of photochemical reactions or prior art specially designed compounds.
摘要翻译： 本文公开了一种用于处理聚合物表面以抵抗生物分子的非特异性结合和细胞附着的方法。 该方法包括以下步骤：向聚合物表面施加电荷以产生带电表面; 将带电表面暴露于富氮聚合物以形成聚合表面; 将聚合的表面暴露于氧化多糖以形成醛表面; 并将醛表面暴露于还原剂。 有利地，提供了产生抵抗非特异性蛋白质结合和细胞附着并避免使用光化学反应或现有技术特别设计的化合物的表面的方法。
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