公开(公告)号：US20230357155A1

公开(公告)日：2023-11-09

申请号：US17932334

申请日：2021-03-17

Applicant: CORTEVA AGRISCIENCE LLC

Inventor： BELGIN CANTURK ,  JAYACHANDRAN DEVARAJ ,  AMARUKA HAZARI ,  CHRISTOPHER KASSL ,  MELISSA LEE ,  FANGZHENG LI ,  CHRISTIAN T. LOWE ,  THOMAS L. SIDDALL ,  GREGORY T. WHITEKER ,  CHUNMING ZHANG

IPC: C07D213/803 ,  C07D401/04 ,  C07D209/04 ,  C07F7/10 ,  C07F5/02

CPC classification number: C07D213/803 ,  C07D401/04 ,  C07D209/04 ,  C07F7/10 ,  C07F5/02

Abstract: The present disclosure relates to improved processes for preparing 4-amino-6-(heterocyclic)picolinates.

公开(公告)号：US20230174490A1

公开(公告)日：2023-06-08

申请号：US17906404

申请日：2021-03-17

Applicant: CORTEVA AGRISCIENCE LLC

Inventor： CHUNMING ZHANG ,  SIYU TU ,  RONALD B. LENG ,  NICHOLAS IRVINE ,  ABRAHAM SCHUITMAN ,  AARON SHINKLE ,  JAYACHANDRAN DEVARAJ ,  CHENGLI ZU

IPC: C07D213/803 ,  C07D401/04

CPC classification number: C07D213/803 ,  C07D401/04 ,  B01J23/44

Abstract: The present disclosure relates to improved methods of synthesizing 6-aryl-4-aminopicolinates, such as arylalkyl and alkyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates.

公开(公告)号：US20220371997A1

公开(公告)日：2022-11-24

申请号：US17808368

申请日：2022-06-23

Applicant: CORTEVA AGRISCIENCE LLC

Inventor： JAYACHANDRAN DEVARAJ ,  NUGZAR GHAVTADZE ,  NICHOLAS M. IRVINE ,  JEREMY KISTER ,  MELISSA LEE ,  RONALD B. LENG ,  RONGRONG [MANDY] LIN ,  RONG LING ,  NOORMOHAMED M. NIYAZ ,  ABRAHAM D. SCHUITMAN ,  AARON A. SHINKLE ,  SIYU TU ,  GREGORY T. WHITEKER ,  CHUNMING ZHANG

IPC: C07D213/803

Abstract: Methods for preparing 5-fluoro-6-(bromo or chloro)picloram analogs, or derivatives thereof, from picloram acid, picloram ester, or the nitrile analog of picloram are provided. The methods include chemical process steps that: (1) introduce a phthaloyl group onto the 4-amino substituent of picloram acid, picloram ester, or the nitrile analog of picloram, (2) add 2 fluorine atoms at the 5,6-positions of the pyridine ring using halex fluorination chemistry, (3) remove the phthaloyl group, hydrolyze the ester or nitrile substituent, and add chlorine or bromine to the 6-position by treatment with an acid and water, and finally, (4) esterify the 5-fluoro-6-(bromo or chloro)picloram acid produced in step (3) to a 5-fluoro-6-(bromo or chloro)picloram ester.

公开(公告)号：US20250011301A1

公开(公告)日：2025-01-09

申请号：US18708365

申请日：2022-11-09

Applicant: CORTEVA AGRISCIENCE LLC

Inventor： MICHAEL L. TRIPPEER ,  CHUNMING ZHANG ,  CHENGLI ZU

IPC: C07D401/12

Abstract: Processes to make intermediates to produce mesoionic pesticides are disclosed. Processes to produce N-(pyrimidin-5-ylmethyl)pyridin-2-amine, an important intermediate, are disclosed.