公开(公告)号：US20230219282A1

公开(公告)日：2023-07-13

申请号：US18096251

申请日：2023-01-12

Applicant: California Institute of Technology

Inventor： Max KUDISCH ,  Jeong Hoon KO ,  Chiara DARAIO ,  Mikhail G. SHAPIRO ,  Di WU ,  Gunho KIM ,  Robert H. GRUBBS ,  Ki-Young YOON

IPC: B29C61/06 ,  A61L31/14 ,  A61L31/12

CPC classification number: B29C61/06 ,  A61L31/14 ,  A61L31/128 ,  A61L2400/16 ,  B29K2995/0012 ,  B29K2509/02

Abstract: Aspects disclosed herein include a composite material comprising: one or more shape memory polymers; and a first additive provided in the shape memory polymer(s); wherein: the first additive increases one or more ultrasound-absorption characteristics of the composite material compared to that of the same shape memory polymer(s) free of said first additive; the composite material is characterized by a composite transition temperature (Tcm,trans); and the composite material or one or more portions thereof undergo a shape change from a temporary shape to a permanent shape when the composite material or said one or more portions thereof are heated to within 35° C. of Tcm,trans or a temperature approximately equal to or greater than Tcm,trans.

公开(公告)号：US20230355242A1

公开(公告)日：2023-11-09

申请号：US18096256

申请日：2023-01-12

Applicant: California Institute of Technology ,  The Regents of the University of California

Inventor： Max KUDISCH ,  Jeong Hoon KO ,  Chiara DARAIO ,  Mikhail G. SHAPIRO ,  Di WU ,  Gunho KIM ,  Robert H. GRUBBS ,  Michael R. HARRISON ,  Sunghoon KIM

IPC: A61B17/12

CPC classification number: A61B17/12136 ,  A61B17/1204 ,  A61B17/12031

Abstract: Aspects disclosed herein include an implantable, detachable, and removable medical device comprising: a therapeutic balloon configured to perform a therapeutic activity inside a living subject; and a focused-ultrasound activatable actuator operably connected to the therapeutic balloon; wherein the actuator is capable of being activated between a closed state and an open state remotely via a focused ultrasound beam; wherein the device is configured to be in an implantation state to facilitate implantation of the device in the living subject, in a therapeutic state to facilitate performance of the therapeutic activity, and subsequently in an expulsion state to facilitate expulsion of the medical device from the living subject; and wherein the implantation state, therapeutic state, and expulsion state are different from each other