公开(公告)号：US20210277453A1

公开(公告)日：2021-09-09

申请号：US17204782

申请日：2021-03-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Mikhail G. SHAPIRO ,  Dan I. PIRANER ,  Mohamad H. ABEDI ,  Brittany MOSER ,  Audrey LEE-GOSSELIN

IPC: C12Q1/6825 ,  B01L7/00 ,  C12N15/63 ,  C12N15/10 ,  C12N15/82 ,  G01N33/53

Abstract: Temperature sensitive transcriptional bioswitches and related genetic circuits and in particular bandpass and/or multiplex genetic circuits, vectors, cells, compositions methods and systems are described.

公开(公告)号：US20190175763A1

公开(公告)日：2019-06-13

申请号：US16213991

申请日：2018-12-07

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Mikhail G. SHAPIRO ,  Jerzy O. SZABLOWSKI

IPC: A61K48/00 ,  A61P21/00 ,  C12N15/113 ,  A61M37/00 ,  A61N7/00 ,  A61K38/17 ,  A61K9/00

Abstract: Provided herein are methods, systems, and related vectors and compositions allowing for noninvasive control of neural circuits. In particular, the methods and systems herein described utilize acoustically targeted chemogenetics to achieve a noninvasive neuromodulation in specifically selected cell-types among spatially selected brain regions.

公开(公告)号：US20230219282A1

公开(公告)日：2023-07-13

申请号：US18096251

申请日：2023-01-12

Applicant: California Institute of Technology

Inventor： Max KUDISCH ,  Jeong Hoon KO ,  Chiara DARAIO ,  Mikhail G. SHAPIRO ,  Di WU ,  Gunho KIM ,  Robert H. GRUBBS ,  Ki-Young YOON

IPC: B29C61/06 ,  A61L31/14 ,  A61L31/12

CPC classification number: B29C61/06 ,  A61L31/14 ,  A61L31/128 ,  A61L2400/16 ,  B29K2995/0012 ,  B29K2509/02

Abstract: Aspects disclosed herein include a composite material comprising: one or more shape memory polymers; and a first additive provided in the shape memory polymer(s); wherein: the first additive increases one or more ultrasound-absorption characteristics of the composite material compared to that of the same shape memory polymer(s) free of said first additive; the composite material is characterized by a composite transition temperature (Tcm,trans); and the composite material or one or more portions thereof undergo a shape change from a temporary shape to a permanent shape when the composite material or said one or more portions thereof are heated to within 35° C. of Tcm,trans or a temperature approximately equal to or greater than Tcm,trans.

公开(公告)号：US20180030501A1

公开(公告)日：2018-02-01

申请号：US15663635

申请日：2017-07-28

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Raymond W. BOURDEAU ,  Anupama LAKSHMANAN ,  Arash FARHADI ,  Mikhail G. SHAPIRO ,  Audrey LEE-GOSSELIN

IPC: C12Q1/10 ,  A61K49/22

CPC classification number: C12Q1/10 ,  A61K49/1896 ,  A61K49/223 ,  C07K14/195 ,  C07K14/32 ,  C12N15/70 ,  C12N15/74

Abstract: Hybrid gas vesicle gene cluster (GVGC) configured for expression in a prokaryotic host are described comprising gas vesicle assembly (GVA) genes native to a GVA prokaryotic species and capable of being expressed in a functional form in the prokaryotic host, and one or more gas vesicle structural (GVS) genes native to one or more GVS prokaryotic species, at least one of the one or more GVS prokaryotic species different from the GVA prokaryotic species, and related gas vesicle reporting (GVR) genetic circuits, genetic, vectors, engineered cells, and related compositions methods and systems to produce GVs, hybrid GVGC and/or image a target site.

公开(公告)号：US20230355242A1

公开(公告)日：2023-11-09

申请号：US18096256

申请日：2023-01-12

Applicant: California Institute of Technology ,  The Regents of the University of California

Inventor： Max KUDISCH ,  Jeong Hoon KO ,  Chiara DARAIO ,  Mikhail G. SHAPIRO ,  Di WU ,  Gunho KIM ,  Robert H. GRUBBS ,  Michael R. HARRISON ,  Sunghoon KIM

IPC: A61B17/12

CPC classification number: A61B17/12136 ,  A61B17/1204 ,  A61B17/12031

Abstract: Aspects disclosed herein include an implantable, detachable, and removable medical device comprising: a therapeutic balloon configured to perform a therapeutic activity inside a living subject; and a focused-ultrasound activatable actuator operably connected to the therapeutic balloon; wherein the actuator is capable of being activated between a closed state and an open state remotely via a focused ultrasound beam; wherein the device is configured to be in an implantation state to facilitate implantation of the device in the living subject, in a therapeutic state to facilitate performance of the therapeutic activity, and subsequently in an expulsion state to facilitate expulsion of the medical device from the living subject; and wherein the implantation state, therapeutic state, and expulsion state are different from each other

公开(公告)号：US20210301298A1

公开(公告)日：2021-09-30

申请号：US17334953

申请日：2021-05-31

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Raymond W. BOURDEAU ,  Anupama LAKSHMANAN ,  Arash FARHADI ,  Mikhail G. SHAPIRO ,  Audrey LEE-GOSSELIN

IPC: C12N15/75 ,  C07K14/32

Abstract: Hybrid gas vesicle gene cluster (GVGC) configured for expression in a prokaryotic host are described comprising gas vesicle assembly (GVA) genes native to a GVA prokaryotic species and capable of being expressed in a functional form in the prokaryotic host, and one or more gas vesicle structural (GVS) genes native to one or more GVS prokaryotic species, at least one of the one or more GVS prokaryotic species different from the GVA prokaryotic species, and related gas vesicle reporting (GVR) genetic circuits, genetic, vectors, engineered cells, and related compositions methods and systems to produce GVs, hybrid GVGC and/or image a target site.

公开(公告)号：US20180038922A1

公开(公告)日：2018-02-08

申请号：US15663600

申请日：2017-07-28

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： George J. LU ,  Mikhail G. SHAPIRO ,  Arash FARHADI ,  Jerzy O. SZABLOWSKI

IPC: G01R33/28 ,  G01R33/50 ,  A61B8/08 ,  A61B5/055 ,  G01R33/48

CPC classification number: G01R33/281 ,  A61B5/055 ,  A61B8/4416 ,  A61B8/481 ,  A61B8/5261 ,  G01R33/4814 ,  G01R33/50 ,  G01R33/5601 ,  G01R33/5602

Abstract: Gas vesicle protein structures and related compositions, methods, and systems for singleplexed and/or multiplexed magnetic resonance imaging of a target site alone or in combination with ultrasound are described, in which the gas vesicle protein structures provide contrast for the imaging.

公开(公告)号：US20170298425A1

公开(公告)日：2017-10-19

申请号：US15384254

申请日：2016-12-19

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Mikhail G. SHAPIRO ,  Dan I. PIRANER ,  Mohamad H. ABEDI ,  Brittany MOSER ,  Audrey LEE-GOSSELIN

IPC: C12Q1/68 ,  C12N15/63 ,  C12N15/82 ,  B01L7/00 ,  G01N33/53 ,  C12N15/10 ,  C12N15/00

CPC classification number: C12Q1/6825 ,  B01L7/52 ,  C12N15/00 ,  C12N15/1055 ,  C12N15/63 ,  C12N15/8217 ,  C12Q1/6804 ,  C12Q2525/30 ,  G01N33/53 ,  C12Q2522/101 ,  C12Q2527/101

Abstract: Temperature sensitive transcriptional bioswitches and related genetic circuits and in particular bandpass and/or multiplex genetic circuits, vectors, cells, compositions methods and systems are described.