公开(公告)号：US20200048201A1

公开(公告)日：2020-02-13

申请号：US16511138

申请日：2019-07-15

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Aurapat Ngamnithiporn ,  Carina I. Jette ,  Shoshana Bachman ,  Scott C. Virgil ,  Sebastian Lackner

IPC: C07D211/86 ,  B01J31/24 ,  C07D309/32 ,  C07D407/06 ,  C07D409/06 ,  C07D309/30 ,  C07D211/76

Abstract: The present disclosure provides methods for enantioselective synthesis of cyclic and acyclic α-quaternary carboxylic acid derivatives via nickel-catalyzed allylic alkylation.

公开(公告)号：US10745354B2

公开(公告)日：2020-08-18

申请号：US16511138

申请日：2019-07-15

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Aurapat Ngamnithiporn ,  Carina I. Jette ,  Shoshana Bachman ,  Scott C. Virgil ,  Sebastian Lackner

IPC: C07C69/75 ,  C07D211/86 ,  C07D407/06 ,  C07D409/06 ,  C07D309/30 ,  C07D211/76 ,  B01J31/24 ,  C07D309/32 ,  C07B37/04

Abstract: The present disclosure provides methods for enantioselective synthesis of cyclic and acyclic α-quaternary carboxylic acid derivatives via nickel-catalyzed allylic alkylation.