公开(公告)号：US20250099443A1

公开(公告)日：2025-03-27

申请号：US18884373

申请日：2024-09-13

Applicant: California Institute of Technology

Inventor： Hao Yu ,  Zachary P. Sercel ,  Samir P. Rezgui ,  Jonathan Farhi ,  Brian M. Stoltz ,  Scott C. Virgil

IPC: A61K31/4375 ,  A61K31/437 ,  A61P35/00 ,  C07D471/06 ,  C07D519/00

Abstract: Disclosed herein are analogs and derivatives of aleutianamine and methods of making the same. Also disclosed herein are methods of treating pancreatic cancer comprising administration of aleutianamine or its analogs.

公开(公告)号：US10526334B2

公开(公告)日：2020-01-07

申请号：US16038968

申请日：2018-07-18

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Eric R. Welin ,  Scott C. Virgil ,  Pamela Tadross ,  Gerit Maria Pototschnig ,  Aurapat (Fa) Ngamnithiporn ,  Kenji Negoro ,  Guillaume Lapointe ,  Max Klatte ,  Christopher Haley ,  Christian Gruenanger ,  Emil Glibstrup ,  Christopher Gilmore ,  Kevin McCormack Allan

IPC: C07D471/18 ,  A61P35/00 ,  C07D401/04

Abstract: (−)-Jorumycin, ecteinascidin 743, saframycin A and related compounds, methods of preparing the same, formulations comprising the compounds, and methods of treating proliferative diseases with the same are provided.

公开(公告)号：US08912347B2

公开(公告)日：2014-12-16

申请号：US13929425

申请日：2013-06-27

Applicant: California Institute of Technology

Inventor： Hosea Nelson ,  Kei Murakami ,  Scott C. Virgil ,  Brian M. Stoltz ,  Jonathan R. Gordon

IPC: C07D313/06 ,  C07D311/78 ,  C07D493/16 ,  C07D493/08 ,  C07D493/18

CPC classification number: C07D311/00 ,  C07D493/08 ,  C07D493/16 ,  C07D493/18

Abstract: Compounds represented by Formula I are provided that include synthetic transtaganolide and basiliolide products. Derivatives of these compounds and methods of synthesis are also provided.

Abstract translation: 提供由式I表示的化合物，其包括合成的经斯曲肽内酯和巴利内酯产物。 还提供了这些化合物的衍生物和合成方法。

公开(公告)号：US20140005416A1

公开(公告)日：2014-01-02

申请号：US13929425

申请日：2013-06-27

Applicant: California Institute of Technology

Inventor： Hosea Nelson ,  Kei Murakami ,  Scott C. Virgil ,  Brian M. Stoltz ,  Jonathan R. Gordon

IPC: C07D493/16 ,  C07D493/08

CPC classification number: C07D311/00 ,  C07D493/08 ,  C07D493/16 ,  C07D493/18

Abstract: Compounds represented by Formula I are provided that include synthetic transtaganolide and basiliolide products. Derivatives of these compounds and methods of synthesis are also provided.

Abstract translation: 提供由式I表示的化合物，其包括合成的经斯曲肽内酯和巴利内酯产物。 还提供了这些化合物的衍生物和合成方法。

公开(公告)号：US10906875B2

公开(公告)日：2021-02-02

申请号：US16427629

申请日：2019-05-31

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Scott C. Virgil ,  David E. White ,  Taiga Yurino ,  Yiyang Liu ,  Douglas C. Behenna ,  Douglas Duquette ,  Christian Eidamshaus

IPC: C07D211/78 ,  C07D211/16 ,  C07D211/18 ,  C07D211/22 ,  C07D211/34 ,  C07D211/38 ,  C07D211/60 ,  C07D211/76 ,  C07D211/88 ,  C07D211/90 ,  C07D211/94 ,  C07D211/96 ,  C07D207/06 ,  C07D207/08 ,  C07D207/10 ,  C07D201/16 ,  C07D207/26 ,  C07D207/263 ,  C07D207/267 ,  C07D207/27 ,  C07D207/273 ,  C07D207/277 ,  C07D207/46 ,  C07D223/04 ,  C07D223/10 ,  C07D241/04 ,  C07D241/08 ,  C07D241/52 ,  C07D265/30 ,  C07D265/32 ,  C07D309/04 ,  C07D309/30 ,  C07D207/16

Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.

公开(公告)号：US10035769B2

公开(公告)日：2018-07-31

申请号：US15366590

申请日：2016-12-01

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Scott C. Virgil ,  David E. White ,  Taiga Yurino ,  Yiyang Liu ,  Douglas C. Behenna ,  Douglas Duquette ,  Christian Eidamshaus

IPC: C07D207/27 ,  C07D207/277 ,  C07D211/76 ,  C07D211/78 ,  C07D211/90 ,  C07D211/96 ,  C07D223/10 ,  C07D265/32

CPC classification number: C07D211/78 ,  C07D207/06 ,  C07D207/08 ,  C07D207/10 ,  C07D207/16 ,  C07D207/26 ,  C07D207/263 ,  C07D207/267 ,  C07D207/27 ,  C07D207/273 ,  C07D207/277 ,  C07D207/46 ,  C07D211/16 ,  C07D211/18 ,  C07D211/22 ,  C07D211/34 ,  C07D211/38 ,  C07D211/60 ,  C07D211/76 ,  C07D211/88 ,  C07D211/90 ,  C07D211/94 ,  C07D211/96 ,  C07D223/04 ,  C07D223/10 ,  C07D241/04 ,  C07D241/08 ,  C07D241/52 ,  C07D265/30 ,  C07D265/32 ,  C07D309/04 ,  C07D309/30

Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.

公开(公告)号：US20220106325A1

公开(公告)日：2022-04-07

申请号：US17263453

申请日：2019-07-26

Applicant: California Institute of Technology ,  The Regents Of The University Of California ,  1200 Pharma LLC

Inventor： Brendan M. O'Boyle ,  Justin A. Hilf ,  Scott C. Virgil ,  Alexander W. Sun ,  Brian M. Stoltz ,  Dylan Conklin ,  Martina S. McDermott ,  Neil A. O'Brien ,  Michael J. Palazzolo ,  Dennis Slamon ,  Michael D. Bartberger

IPC: C07D491/107 ,  C07D413/14 ,  C07D498/10 ,  C07D401/14 ,  C07D495/10 ,  A61P35/00

Abstract: The present disclosure provides compounds and compositions that are CDK inhibitors selective for CDK4 and/or CDK6, and methods of use thereof.

公开(公告)号：US20210155592A1

公开(公告)日：2021-05-27

申请号：US17164204

申请日：2021-02-01

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Scott C. Virgil ,  David E. White ,  Taiga Yurino ,  Yiyang Liu ,  Douglas C. Behenna ,  Douglas Duquette ,  Christian Eidamshaus

IPC: C07D211/78 ,  C07D265/32 ,  C07D211/60 ,  C07D207/16 ,  C07D223/10 ,  C07D309/04 ,  C07D223/04 ,  C07D241/04 ,  C07D241/08 ,  C07D241/52 ,  C07D207/06 ,  C07D265/30 ,  C07D207/08 ,  C07D207/10 ,  C07D207/26 ,  C07D207/263 ,  C07D207/27 ,  C07D207/46 ,  C07D211/16 ,  C07D211/18 ,  C07D211/22 ,  C07D211/34 ,  C07D211/38 ,  C07D211/76 ,  C07D211/88 ,  C07D211/94 ,  C07D211/96 ,  C07D309/30 ,  C07D207/267 ,  C07D207/273 ,  C07D207/277 ,  C07D211/90

Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.

公开(公告)号：US10745354B2

公开(公告)日：2020-08-18

申请号：US16511138

申请日：2019-07-15

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Aurapat Ngamnithiporn ,  Carina I. Jette ,  Shoshana Bachman ,  Scott C. Virgil ,  Sebastian Lackner

IPC: C07C69/75 ,  C07D211/86 ,  C07D407/06 ,  C07D409/06 ,  C07D309/30 ,  C07D211/76 ,  B01J31/24 ,  C07D309/32 ,  C07B37/04

Abstract: The present disclosure provides methods for enantioselective synthesis of cyclic and acyclic α-quaternary carboxylic acid derivatives via nickel-catalyzed allylic alkylation.

公开(公告)号：US20200157102A1

公开(公告)日：2020-05-21

申请号：US16692518

申请日：2019-11-22

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Eric R. Welin ,  Scott C. Virgil ,  Pamela Tadross ,  Gerit M. Pototschnig ,  Aurapat (Fa) Ngamnithiporn ,  Kenji Negoro ,  Guillaume Lapointe ,  Max Klatte ,  Christopher Haley ,  Christian Gruenanger ,  Emil Glibstrup ,  Christopher Gilmore ,  Kevin McCormack Allan

IPC: C07D471/18 ,  C07D401/04 ,  A61P35/00

Abstract: (−)-Jorumycin, ecteinascidin 743, saframycin A and related compounds, methods of preparing the same, formulations comprising the compounds, and methods of treating proliferative diseases with the same are provided.