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公开(公告)号：US20250052679A1
公开(公告)日：2025-02-13
申请号：US18930194
申请日：2024-10-29
Applicant: Cambridge Enterprise Limited
Inventor： Gita Khalili Moghaddam , Christopher Robin Lowe , Jeffrey Blyth
Abstract: The present invention relates to sensors for detecting the presence or measuring the concentration of a target analyte, the sensor comprising: (i) a first phase comprising a first crosslinked polymer: (ii) a second phase comprising a second crosslinked polymer: and (ill) a target analyte recognition agent: the first phase and second phase arranged to form an optical grating. The first crosslinked polymer comprises low amounts of a crosslinking agent. The present invention also relates to methods of making a sensor for detecting the presence or measuring the concentration of a target analyte.
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公开(公告)号：US12163883B2
公开(公告)日：2024-12-10
申请号：US17792017
申请日：2021-01-13
Applicant: Cambridge Enterprise Limited
Inventor： Gita Khalili Moghaddam , Christopher Robin Lowe , Jeffrey Blyth
Abstract: The present invention relates to sensors for detecting the presence or measuring the concentration of a target analyte, the sensor comprising: (i) a first phase comprising a first crosslinked polymer; (ii) a second phase comprising a second crosslinked polymer; and (ill) a target analyte recognition agent; the first phase and second phase arranged to form an optical grating. The first crosslinked polymer comprises low amounts of a crosslinking agent. The present invention also relates to methods of making a sensor for detecting the presence or measuring the concentration of a target analyte.
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公开(公告)号：US20230053938A1
公开(公告)日：2023-02-23
申请号：US17792017
申请日：2021-01-13
Applicant: Cambridge Enterprise Limited
Inventor： Gita Khalili Moghaddam , Christopher Robin Lowe , Jeffrey Blyth
Abstract: The present invention relates to sensors for detecting the presence or measuring the concentration of a target analyte, the sensor comprising: (i) a first phase comprising a first crosslinked polymer; (ii) a second phase comprising a second crosslinked polymer; and (ill) a target analyte recognition agent; the first phase and second phase arranged to form an optical grating. The first crosslinked polymer comprises low amounts of a crosslinking agent. The present invention also relates to methods of making a sensor for detecting the presence or measuring the concentration of a target analyte.
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公开(公告)号：US09012110B2
公开(公告)日：2015-04-21
申请号：US14143921
申请日：2013-12-30
Applicant: Cambridge Enterprise Limited
CPC classification number: G03H1/0465 , G03H1/00 , G03H1/0005 , G03H1/0244 , G03H1/0248 , G03H1/0486 , G03H2001/0044 , G03H2001/0415 , G03H2001/186 , G03H2001/2231 , G03H2222/33 , G03H2240/20 , G03H2260/16 , G03H2260/62 , G03H2270/52
Abstract: A method for the production of a holographic sensor which comprises a support medium supporting a reflection hologram wherein the support medium interacts with its physical or chemical environment to create an optical response which is a change in one or more optical properties of the hologram, the method comprising the steps of: a) introducing a colloidal dispersion of a recording material into the support medium; and b) ablating the colloidal particles of the recording material using a pulsed laser to form the holographic element in the support medium. The method of production can be used to introduce a reflection holographic grating into a hydrophobic support medium, in particular, polydimethylsiloxane (PDMS), which possesses an extraordinary ability to swell in the presence of both liquid and/or gaseous low molecular weight hydrocarbons and organic solvents and thus has many applications as a holographic sensor.
Abstract translation: 一种用于生产全息传感器的方法，其包括支撑反射全息图的支撑介质，其中支撑介质与其物理或化学环境相互作用以产生作为全息图的一个或多个光学特性的变化的光学响应，该方法 包括以下步骤：a）将记录材料的胶体分散体引入载体介质中; 和b）使用脉冲激光烧蚀记录材料的胶体颗粒，以在支撑介质中形成全息元件。 生产方法可用于将反射全息光栅引入到疏水性支持介质，特别是聚二甲基硅氧烷（PDMS）中，聚二甲基硅氧烷（PDMS）在液态和/或气态低分子量烃和有机物存在下具有非凡的溶胀能力 溶剂，因此作为全息传感器具有许多应用。
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