公开(公告)号：US20190106413A1

公开(公告)日：2019-04-11

申请号：US16212455

申请日：2018-12-06

Applicant: Cancer Research Technology Limited

Inventor： Keith Jones ,  Carl Rye ,  Nicola Chessum ,  Matthew Cheeseman ,  Adele E, Pasqua ,  Kurt G, Pike ,  Paul F. Faulder

IPC: C07D405/12 ,  C07D491/056 ,  C07D487/08 ,  C07D471/04 ,  C07D417/14 ,  C07D405/14 ,  C07D409/12 ,  C07D407/12 ,  C07D319/18 ,  C07D417/12

Abstract: The present invention relates to compounds of formula I as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.