公开(公告)号：US20240000835A1

公开(公告)日：2024-01-04

申请号：US18038581

申请日：2021-11-24

Applicant: Cancer Research Technology Limited

Inventor： Francis MUSSAI ,  Carmela De Santo

IPC: A61K35/17 ,  C12N5/0783 ,  C07K14/435 ,  C07K16/30 ,  C07K16/28 ,  A61P35/00 ,  A61K39/00

CPC classification number: A61K35/17 ,  C12N5/0636 ,  C12N5/0646 ,  C07K14/435 ,  C07K16/3084 ,  C07K16/2803 ,  A61P35/00 ,  A61K39/4631 ,  A61K39/4613 ,  A61K39/4611 ,  A61K39/464411 ,  C07K16/2863 ,  A61K39/464404 ,  A61K39/464471 ,  A61K2239/28 ,  A61K2239/13

Abstract: The invention relates to nucleic acid constructs comprising a combination of a first sequence encoding a CAR and second sequence encoding an amino acid transporter, and to cells comprising such nucleic acid constructs. It also relates to methods of manufacturing said cells, and to pharmaceutical compositions comprising said nucleic acid constructs or cells, for use in the treatment of diseases with cellular amino-acid depletion such as cancer.