公开(公告)号：US10919896B2

公开(公告)日：2021-02-16

申请号：US16335379

申请日：2017-09-22

Applicant: Cancer Research Technology Limited

Inventor： Emma L. Carswell ,  Mark David Charles ,  Anne Cochi ,  Benjamin J. Dugan ,  Chukuemeka Tennyson Ekwuru ,  Fred Elustondo ,  Katherine M. Fowler ,  Frederic Georges Marie Leroux ,  Nathaniel J. T. Monck ,  Gregory R. Ott ,  Jonathan R. Roffey ,  Gurwinder Sidhu ,  Neil Tremayne

IPC: C07D401/14 ,  C07D487/02 ,  A61P35/00

Abstract: The present invention relates to compounds of formula (I), and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity: wherein X, R1, R2, and n are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated.