公开(公告)号：US09914730B2

公开(公告)日：2018-03-13

申请号：US14038915

申请日：2013-09-27

Applicant: Ignyta, Inc. ,  Cancer Research Technology Limited

Inventor： Henry J. Breslin ,  Bruce D. Dorsey ,  Benjamin J Dugan ,  Katherine M. Fowler ,  Robert L Hudkins ,  Eugen F. Mesaros ,  Nathaniel J. T. Monck ,  Emma L. Morris ,  Ikeoluwa Olowoye ,  Gregory R. Ott ,  Gregoire A. Pave ,  Jonathan R. Roffey ,  Christelle N. Soudy ,  Ming Tao ,  Craig A. Zificsak ,  Allison L. Zulli

IPC: A61K31/675 ,  C07D471/04 ,  C07D519/00 ,  C07D493/08 ,  C07D498/04 ,  C07F9/6584

CPC classification number: C07D471/04 ,  C07D493/08 ,  C07D498/04 ,  C07D519/00 ,  C07F9/6584

Abstract: The present application provides azaquinazoline compounds as defined herein. This application further describes compositions comprising the same. These azaquinazoline compounds and their salts have atypical protein kinase C (“aPKC”) inhibitory activity, and may be used to treat proliferative disorders.

公开(公告)号：US10919896B2

公开(公告)日：2021-02-16

申请号：US16335379

申请日：2017-09-22

Applicant: Cancer Research Technology Limited

Inventor： Emma L. Carswell ,  Mark David Charles ,  Anne Cochi ,  Benjamin J. Dugan ,  Chukuemeka Tennyson Ekwuru ,  Fred Elustondo ,  Katherine M. Fowler ,  Frederic Georges Marie Leroux ,  Nathaniel J. T. Monck ,  Gregory R. Ott ,  Jonathan R. Roffey ,  Gurwinder Sidhu ,  Neil Tremayne

IPC: C07D401/14 ,  C07D487/02 ,  A61P35/00

Abstract: The present invention relates to compounds of formula (I), and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity: wherein X, R1, R2, and n are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated.

公开(公告)号：US09896446B2

公开(公告)日：2018-02-20

申请号：US14975605

申请日：2015-12-18

Applicant: IGNYTA, INC. ,  Cancer Research Technology Limited

Inventor： Henry J. Breslin ,  Bruce D. Dorsey ,  Benjamin J. Dugan ,  Robert L. Hudkins ,  Eugen F. Mesaros ,  Gregory R. Ott ,  Craig A. Zificsak ,  Allison L. Zulli ,  Ming Tao ,  Katherine M. Fowler ,  Emma L. Morris ,  Gregoire A. Pave ,  Jonathan R. A. Roffey ,  Nathaniel J. T. Monck ,  Christelle N. Soudy ,  Ikeoluwa Olowoye

IPC: A61K31/407 ,  C07D471/04 ,  C07D519/00 ,  C07D493/08 ,  C07D498/04 ,  C07F9/6584

CPC classification number: C07D471/04 ,  C07D493/08 ,  C07D498/04 ,  C07D519/00 ,  C07F9/6584

Abstract: The present application provides a compound of formula (I) or a salt thereof, wherein R7, R8, R9, G, and X are as defined herein. This application further describes compositions comprising the same. Compounds of formula (I) and their salts have aPKC inhibitory activity, and may be used to treat proliferative diseases.