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公开(公告)号：US11565255B2
公开(公告)日：2023-01-31
申请号：US17168763
申请日：2021-02-05
发明人： Liang Bai , Tengfei Guo , Lei Wang , Xinying Zhou , Juan Xin , Baolian Li , Li Ma , Libing Dong , Jing Cheng
摘要： A valve system for driving fluid and a method for using the same are provided. The valve system includes a fluid unit far away from the rotation center, a fluid unit close to the rotation center, a fluid transferring unit and a gas path pipeline for communicating the fluid unit close to the rotation center with the fluid unit far away from the rotation center. A rotation radius of a fluid outlet of the fluid unit far away from the rotation center is greater than that of a fluid inlet of the fluid unit close to the rotation center. The fluid outlet of the fluid unit far away from the rotation center is located at an end thereof away from the rotation center, and the fluid inlet of the fluid unit close to the rotation center is located at an end thereof close to the rotation center.
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公开(公告)号：US20210322983A1
公开(公告)日：2021-10-21
申请号：US17168763
申请日：2021-02-05
发明人： Liang Bai , Tengfei Guo , Lei Wang , Xinying Zhou , Juan Xin , Baolian Li , Li Ma , Libing Dong , Jing Cheng
摘要： A valve system for driving fluid and a method for using the same are provided. The valve system includes a fluid unit far away from the rotation center, a fluid unit close to the rotation center, a fluid transferring unit and a gas path pipeline for communicating the fluid unit close to the rotation center with the fluid unit far away from the rotation center. A rotation radius of a fluid outlet of the fluid unit far away from the rotation center is greater than that of a fluid inlet of the fluid unit close to the rotation center. The fluid outlet of the fluid unit far away from the rotation center is located at an end thereof away from the rotation center, and the fluid inlet of the fluid unit close to the rotation center is located at an end thereof close to the rotation center.
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公开(公告)号：US10099218B2
公开(公告)日：2018-10-16
申请号：US15356461
申请日：2016-11-18
发明人： Lei Wang , Xinying Zhou , Li Ma , Juan Xin , Mingxian Lin , Jinhai Feng
摘要： In one aspect, disclosed herein are methods for packaging biochips, including microfluidic chips. The method can comprise bonding a substrate and a cover slide, packaging the bonded chip, creating a vacuum in the package, and applying a pressure on the packaged chip. The method is particularly useful for minimizing bubble formation during low-cost and mass production of microfluidic chips.
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公开(公告)号：US10300483B2
公开(公告)日：2019-05-28
申请号：US15123978
申请日：2015-03-06
发明人： Lei Wang , Guohao Zhang , Xinying Zhou , Juan Xin , Yao Zhang , Mingxian Lin , Guoliang Huang , Can Wang , Wanli Xing , Jing Cheng
IPC分类号： B01L99/00 , B01L3/00 , C12Q1/6869
摘要： A multi-index detection microfluidic chip is provided. A bottom plate (1) and a cover plate (2) that matches the bottom plate (1) and seals it are provided in the microfluidic chip. The center of the microfluidic chip has a through-hole (3). The bottom plate (1) has one or more wave-shaped main channel(s) (4), one end of each of the main channel (4) connected to a sample injection hole (9) on the bottom plate (1), and the other end connected to an exhaust hole (10) on the bottom plate (1). The valley on the main channel (1) is distal to the through-hole (3), and the peak is proximal to the through-hole (3). Each valley of the main channel (1) is connected to a reaction chamber (6) by a linking channel (5). The linking channel (5) comprises one or more buffering chambers (7). The microfluidic chip can be used in detection by fluorescence, turbidity, color, detection equipment, and/or direct observation by the naked eyes. The detection is real-time as the reaction occurs or after the reaction.
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