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公开(公告)号：US20240075172A1
公开(公告)日：2024-03-07
申请号：US18263453
申请日：2021-12-07
发明人： Huawei CAI , Xiaofeng LU , Hao YANG , Lin LI , Rong TIAN , Jingqiu CHENG
CPC分类号： A61K51/1093 , C07K16/2863 , C07K2317/31
摘要： Disclosed are a gallium 68 labeled affibody protein PET imaging agent and a use thereof; the imaging agent comprises 68Ga-Z-tri; the 68Ga-Z-tri is obtained by labeling an affibody protein with gallium 68; the affibody protein comprises a PDGFR-β targeting trimer affibody protein Z-tri; and the amino acid sequence listing of the affibody protein Z-tri is as shown in SEQ ID NO. 1. According to the present invention, the utilized PDGFR-β targeting trimer affibody having a unique amino acid sequence has the characteristics of high affinity and high stability compared with a monomer affibody and a dimer affibody, can greatly increase a nuclide labeling rate, and achieves the effectiveness thereof as a PET imaging probe.
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公开(公告)号：US11577240B2
公开(公告)日：2023-02-14
申请号：US17166546
申请日：2021-02-03
发明人： Xinying Zhou , Lei Wang , Liang Bai , Tengfei Guo , Shuo Li , Baolian Li , Bin Zhuang , Xiang Chen , Hongju Guo , Xiaolei Zhao , Wanli Xing , Jing Cheng
IPC分类号： B01L3/00
摘要： A liquid storage and controlled-release device and a biological detection chip. The liquid storage and controlled-release device comprises a liquid storage capsule with a liquid storage body which is deformable under a pressure, and a sealing layer for sealing the liquid storage body. A support platform is provided right below the liquid storage capsule and tightly connected with the liquid storage capsule, wherein, a directional release chamber is provided at the middle of the support platform, and the directional release chamber is provided with a guiding chamber for collecting the liquid and a sharp edge for inducing break. Compared with the conventional technology, the opening for liquid release is at the end far away from the rotation center, so that the liquid can be released completely by the centrifugal force, ensuring the quantitative release of stored liquid and reducing the influence on the accuracy of the subsequent detection.
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公开(公告)号：US11565255B2
公开(公告)日：2023-01-31
申请号：US17168763
申请日：2021-02-05
发明人： Liang Bai , Tengfei Guo , Lei Wang , Xinying Zhou , Juan Xin , Baolian Li , Li Ma , Libing Dong , Jing Cheng
摘要： A valve system for driving fluid and a method for using the same are provided. The valve system includes a fluid unit far away from the rotation center, a fluid unit close to the rotation center, a fluid transferring unit and a gas path pipeline for communicating the fluid unit close to the rotation center with the fluid unit far away from the rotation center. A rotation radius of a fluid outlet of the fluid unit far away from the rotation center is greater than that of a fluid inlet of the fluid unit close to the rotation center. The fluid outlet of the fluid unit far away from the rotation center is located at an end thereof away from the rotation center, and the fluid inlet of the fluid unit close to the rotation center is located at an end thereof close to the rotation center.
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公开(公告)号：US20210322983A1
公开(公告)日：2021-10-21
申请号：US17168763
申请日：2021-02-05
发明人： Liang Bai , Tengfei Guo , Lei Wang , Xinying Zhou , Juan Xin , Baolian Li , Li Ma , Libing Dong , Jing Cheng
摘要： A valve system for driving fluid and a method for using the same are provided. The valve system includes a fluid unit far away from the rotation center, a fluid unit close to the rotation center, a fluid transferring unit and a gas path pipeline for communicating the fluid unit close to the rotation center with the fluid unit far away from the rotation center. A rotation radius of a fluid outlet of the fluid unit far away from the rotation center is greater than that of a fluid inlet of the fluid unit close to the rotation center. The fluid outlet of the fluid unit far away from the rotation center is located at an end thereof away from the rotation center, and the fluid inlet of the fluid unit close to the rotation center is located at an end thereof close to the rotation center.
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公开(公告)号：US11998239B2
公开(公告)日：2024-06-04
申请号：US18119847
申请日：2023-03-10
IPC分类号： A61B17/34
CPC分类号： A61B17/3496 , A61B17/3403 , A61B17/3417 , A61B2017/3405 , A61B2017/3454
摘要： A puncture instrument kit includes a puncture rod, mesh, and sheath. The puncture rod consists of a puncture head, puncture rod body, and handle. One end of the puncture rod body is connected to the handle and the other end is integrated with the puncture head. The puncture head is arc-shaped with an end gradually tapering to form a tip. The tip of the puncture head is circumferentially designed with a groove for fixing a thread during surgery. The puncture head is smoothly connected with the puncture rod body, and the line between the tip of the puncture head and puncture rod body is at an obtuse angle of 130-140° relative to the puncture rod body. The sheath is sleeved on the puncture rod with the rod tip exposed. The mesh and sheath are designed as separate or integrated, and the tip of the puncture rod is provided with a shape-matching detachable silicone protective sleeve.
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公开(公告)号：US20230405111A1
公开(公告)日：2023-12-21
申请号：US18017746
申请日：2021-07-12
发明人： Hanshuo YANG , Yuquan WEI
IPC分类号： A61K39/245 , C12N5/0781 , C12N13/00 , A61P35/00
CPC分类号： A61K39/245 , C12N5/0635 , C12N13/00 , A61P35/00 , C12N2710/16234 , C12N2710/16261 , A61K2039/5154
摘要： The invention belongs to the field of biotechnology, and relates to an allogeneic B cell vaccine against various human-susceptible viruses and a preparation method therefor. The vaccine has anti-tumor and/or anti-viral preventive and/or therapeutic effects. Specifically, the present invention provides a B cell composition, wherein comprising an allogeneic B cell and a virus antigen, the B cell composition is irradiated with a certain dose of ionizing irradiation. The present invention also provides a B cell vaccine, comprising the above B cell composition. The invention also provides a preparation method for the B cell vaccine and a method and system for improving the antigen presentation ability of the B cell.
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公开(公告)号：US20220323512A1
公开(公告)日：2022-10-13
申请号：US17681321
申请日：2022-02-25
发明人： Shizhou Wu , Lei Lei , Yunjie Liu
IPC分类号： A61K35/74 , A61P31/04 , C12N15/113 , C12N1/20
摘要： The present disclosure discloses a methicillin-resistant staphylococcus aureus mutant strain and use thereof, and belongs to the field of molecular biology and microorganisms. The methicillin-resistant staphylococcus aureus mutant strain disclosed by the present disclosure has a relatively low exopolysaccharide synthesis ability and a relatively low biofilm metabolism ability, but it is sensitive to an antibiotic cefoxitin. The mutant strain can be used for treating a related disease caused by methicillin-resistant staphylococcus aureus infection through an endogenous ecological treatment strategy. The present disclosure provides a new idea for treating the disease.
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公开(公告)号：US20220313896A1
公开(公告)日：2022-10-06
申请号：US17220940
申请日：2021-04-02
发明人： Xiang TONG
摘要： The present invention discloses a device for removing sputum scabs of a respiratory tract, comprising an outer housing. A fluid hole is designed on a removing part at the front end of the outer housing, and the fluid hole is respectively communicated with a liquid pump and an air pump, so that the device can be extended into the lower respiratory tract of the patient during use. Then, the sputum scabs attached to the inner wall of the respiratory tract can be softened and removed by alternately spraying liquid and gas from the fluid hole, and the removed sputum scabs can be sucked out through negative pressure holes, so as to prevent the scabs of the secretions of the lower respiratory tract from blocking the tracheae.
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9.发明申请公开(公告)号：US20220148301A1
公开(公告)日：2022-05-12
申请号：US17606751
申请日：2020-09-29
申请人： West China Hospital of Sichuan University , University of Electronic science and Technology of China
发明人： Na Hu , Su Lv , Shi Gu , Tianwei Zhang
摘要： This invention discloses an auxiliary diagnostic model and an image processing method for detecting acute ischemic stroke. This refers to the technical field of medical image processing. The technical essentials are described as follow: the presented deep-learning model is based on generative adversarial networks (GANs), comprising a generator (G) and a discriminator (D). G is the first three-dimensional convolutional neural network, used to synthesize realistic images from raw data, while D is the second three-dimensional convolutional neural network, used to classify images as real or fake (synthetic). The presented GAN model can learn the mapping relationship from non-enhanced computed tomography (NECT) images to T2-weighted fluid-attenuation inversion recovery (FLAIR) magnetic resonance imaging (MRI), then converting the raw CT to synthetic FLAIR with high sensitivity. This improves the efficiency of emergency scanning in acute ischemic stroke, reaching sensitivity that is poor in CT interpretation and immediacy that is limited in MRI examination.
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10.发明申请公开(公告)号：US20210332348A1
公开(公告)日：2021-10-28
申请号：US17237495
申请日：2021-04-22
发明人： Xiang CHEN , Lei WANG , Su LI , Longtang ZHENG , Yanan WANG , Fei WEN , Juan XIN , Wentian ZHANG , Jing CHENG
IPC分类号： C12N15/10 , C12Q1/6806
摘要： A nucleic acid extraction composition, reagents and kits containing the same and uses thereof. Provided is a nucleic acid extraction and purification reagent free of volatile organic solvents, which prevents the damage of volatile organic solvents to people and greatly improves the timeliness of nucleic acid extraction and purification, making the operation extremely simple, and the nucleic acid can be obtained within 10 minutes. The obtained nucleic acid may be used for biological reactions such as PCR, NASBA, LAMP and RPA. Moreover, the reagents of the present disclosure may be used to extract nucleic acids of cells, bacteria, fungi, DNA viruses and RNA viruses from various samples such as blood, throat swab preserving fluid, saliva, urine, sputum, excrement and the like, and very suitable for clinical and scientific research uses.
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