公开(公告)号：US20130253426A1

公开(公告)日：2013-09-26

申请号：US13603296

申请日：2012-09-04

申请人： Carey V. Campbell ,  Robert L. Cleek ,  Daniel L. Crandall ,  James F. Davidson ,  Paul D. Drumheller ,  Cody L. Hartman ,  Theresa A. Holland ,  Thane L. Krazler ,  Mei Li ,  Gregory LoStracco ,  Bruce M. Steinhaus ,  Benjamin M. Trapp ,  Thomas G. Triebes

发明人： Carey V. Campbell ,  Robert L. Cleek ,  Daniel L. Crandall ,  James F. Davidson ,  Paul D. Drumheller ,  Cody L. Hartman ,  Theresa A. Holland ,  Thane L. Krazler ,  Mei Li ,  Gregory LoStracco ,  Bruce M. Steinhaus ,  Benjamin M. Trapp ,  Thomas G. Triebes

IPC分类号： A61M25/10

CPC分类号： A61M25/10 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/602 ,  A61M2025/105 ,  A61M2025/1081 ,  F04C2270/0421

摘要： The invention is directed to eluting medical devices that enable consistent “on-demand” delivery of therapeutic agents to a vessel. The medical device of the current invention comprises an expandable member, a hydrophilic coating comprising at least one therapeutic agent about the expandable member or structural layer and an outer sheath with a variably permeable microstructure. The design and methods disclosed herein ensures that therapeutic agent delivery occurs essentially only during expansion of the expandable member, minimizing coating and/or therapeutic agent loss to the bloodstream and providing controlled delivery to the treatment site.

摘要翻译： 本发明涉及洗脱能够使治疗剂向血管进行一致“按需”递送的医疗装置。 本发明的医疗装置包括可膨胀构件，亲水性涂层，其包括围绕可膨胀构件或结构层的至少一种治疗剂和具有可变可渗透微结构的外护套。 本文公开的设计和方法确保治疗剂递送基本上仅在可膨胀构件的膨胀期间发生，使涂覆和/或治疗剂对血流的损失最小化并提供受控递送至治疗部位。