公开(公告)号：US20240342346A1

公开(公告)日：2024-10-17

申请号：US18633245

申请日：2024-04-11

申请人： Boston Scientific Scimed, Inc.

发明人： Andrew J. Ro ,  Nicholas Michael Job ,  Aaron Cooper Foss ,  Amanda Maxwell

IPC分类号： A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61M25/10

CPC分类号： A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61M2025/105

摘要： A medical device may be coated with a therapeutic composition that includes everolimus. Everolimus crystals may be coated with a mixture of excipients to form encapsulated everolimus crystals suspended in a coating composition. An illustrative coating composition may comprise a mixture of excipients including a bioresorbable or thermo-gelling polymer and a plasticizing agent and a therapeutic agent. The bioresorbable or thermo-gelling polymer may be selected from polycaprolactone (PCL) or poloxamer.

公开(公告)号：US12109332B2

公开(公告)日：2024-10-08

申请号：US18386896

申请日：2023-11-03

申请人： The Regents of the University of California ,  Silq Technologies Corporation

发明人： Brian T. McVerry ,  Ethan Rao ,  Richard B. Kaner ,  Na He

IPC分类号： A61L31/00 ,  A61L29/08 ,  C08F220/30 ,  C08F220/34 ,  C08F220/38 ,  C08F293/00 ,  C09D5/00 ,  C09D153/00

CPC分类号： A61L31/00 ,  A61L29/085 ,  C08F220/30 ,  C08F220/34 ,  C08F220/382 ,  C08F293/005 ,  C09D5/00 ,  C09D153/00 ,  A61L2420/02 ,  C08F2438/01

摘要： Disclosed herein are compositions to use in biofouling-resistant coatings, biofouling-resistant coatings, methods of making biofouling-resistant coatings, biofouling-resistant devices, and methods of making biofouling-resistant devices.

公开(公告)号：US12104136B2

公开(公告)日：2024-10-01

申请号：US17326041

申请日：2021-05-20

申请人： Merit Medical Ireland Limited

发明人： Martin Moran ,  Emmanouil Kasotakis

IPC分类号： C10M107/44 ,  A61L29/08 ,  A61M25/00 ,  C10M107/28 ,  C10N40/00 ,  C10N50/00

CPC分类号： C10M107/44 ,  A61L29/085 ,  A61M25/0045 ,  C10M107/28 ,  A61L2400/10 ,  A61L2420/02 ,  A61L2420/06 ,  A61L2420/08 ,  A61M2025/0046 ,  C10M2209/0845 ,  C10M2209/0863 ,  C10M2217/0453 ,  C10N2040/50 ,  C10N2050/023

摘要： Coatings for medical devices having selectable levels of durability and lubricity are disclosed. The coatings include polymeric material components, the characteristics and relative amounts of which can be selected to provide target levels of durability and lubricity. Methods of making the coatings for medical devices are also disclosed.

公开(公告)号：US20240316901A1

公开(公告)日：2024-09-26

申请号：US18693012

申请日：2022-10-03

申请人： Nordson Corporation

发明人： Thomas Bash ,  Andrew Schombs ,  Lilian Campbell

IPC分类号： B32B7/12 ,  A61L29/04 ,  A61L29/08 ,  B32B1/08 ,  B32B15/02 ,  B32B15/08 ,  B32B27/08 ,  B32B27/28 ,  B32B27/32 ,  B32B27/34 ,  B32B27/40 ,  B32B37/12

CPC分类号： B32B7/12 ,  A61L29/041 ,  A61L29/085 ,  B32B1/08 ,  B32B15/02 ,  B32B15/08 ,  B32B27/08 ,  B32B27/285 ,  B32B27/322 ,  B32B27/34 ,  B32B27/40 ,  B32B37/1284 ,  B32B2255/10 ,  B32B2255/26 ,  B32B2274/00 ,  B32B2307/7376 ,  B32B2307/748 ,  B32B2325/00 ,  B32B2327/18 ,  B32B2535/00 ,  B32B2597/00

摘要： Multilayer tubes including an inner layer and a tie layer are described. The inner layer includes a fluorinated polymer, and has an inner surface defining an inner diameter of the multilayer tube and an outer surface separated from the inner surface by a thickness of the inner layer. The tie layer includes a functionalized styrene block copolymer and is disposed on the outer surface of the inner layer. When the multilayer tube further includes an outer layer, the multilayer tubes exhibit improved peel strength as compared to multilayer tubes including the inner layer and outer layer alone. Methods of manufacturing the multilayer tubes and articles comprising the multilayer tubes are also described.

公开(公告)号：US20240315250A1

公开(公告)日：2024-09-26

申请号：US18734194

申请日：2024-06-05

申请人： Nevada Naturals Inc.

发明人： Anthony J. Sawyer ,  Richard F. Stockel

IPC分类号： A01N47/44 ,  A01N37/36 ,  A01N43/16 ,  A61L15/20 ,  A61L15/46 ,  A61L15/60 ,  A61L17/00 ,  A61L26/00 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L29/08 ,  A61L29/14 ,  A61L29/16 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16

CPC分类号： A01N47/44 ,  A01N37/36 ,  A01N43/16 ,  A61L15/20 ,  A61L15/46 ,  A61L15/60 ,  A61L17/005 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L29/085 ,  A61L29/145 ,  A61L29/16 ,  A61L31/10 ,  A61L31/145 ,  A61L31/16 ,  A01N2300/00 ,  A61L26/0066 ,  A61L2300/406 ,  A61L2400/04

摘要： Compositions are provided that have at least two of three active ingredients. The active ingredients maybe a salt having a cation NαC8-C16 alkanoyl-L di-basic amino acid —C1-C4 alkyl ester, a glycerol monoester of a fatty acid and a sugar ester of a fatty acid. The compositions are useful in methods of killing or inhibiting planktonic bacteria or fungi and bacteria or fungi embedded in a biofilm and prevention of biofilm formation on surfaces. The composition may further comprise a hydrogel and a benefit agent such as an antibiotic that can be solubilized by the hydrogel and supplied to the biofilm matrix by the active ingredients of the composition. Devices such as chronic wound coverings coated with the composition are also provided. Methods of preserving products with the composition are also provided.

公开(公告)号：US12097307B2

公开(公告)日：2024-09-24

申请号：US17377124

申请日：2021-07-15

申请人： Massachusetts Institute of Technology ,  The Children's Medical Center Corporation

发明人： Arturo Vegas ,  Joshua C. Doloff ,  Omid Veiseh ,  Minglin Ma ,  Robert S. Langer ,  Daniel G. Anderson

IPC分类号： A61K9/50 ,  A61K9/00 ,  A61K9/48 ,  A61K35/39 ,  A61K47/36 ,  A61L29/08 ,  A61L31/10 ,  A61L33/08 ,  C07D487/04 ,  C08B37/00 ,  C12N5/00 ,  C12N5/071

CPC分类号： A61L29/085 ,  A61K9/0024 ,  A61K9/4816 ,  A61K9/5036 ,  A61K35/39 ,  A61K47/36 ,  A61L31/10 ,  A61L33/08 ,  C07D487/04 ,  C08B37/0084 ,  C12N5/0012 ,  C12N5/0677

摘要： Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body.

公开(公告)号：US20240299630A1

公开(公告)日：2024-09-12

申请号：US18120330

申请日：2023-03-10

申请人： Bard Access Systems, Inc.

发明人： Ejaz Sajedul Haque ,  Nicholas P. Papadopoulos ,  Brendan Laine ,  James L. Freasier

IPC分类号： A61L29/08 ,  A61L29/16

CPC分类号： A61L29/085 ,  A61L29/16 ,  A61L2300/404 ,  A61L2300/442 ,  A61L2300/608 ,  A61L2420/02

摘要： Coated medical devices include coated catheters. For example, a coated catheter can include a catheter tube of a tubular substrate and a coating thereover. The tubular substrate can be of a first polymeric material transparent to electromagnetic radiation in a range of visible light. The coating can be of a second polymeric material anchored to the tubular substrate by chain ends of the second polymeric material impregnated in the first polymeric material by way of a spent visible-light photoinitiator. Methods of coating can include methods of coating medical devices such as the coated catheter. For example, a method of coating can include irradiating a tubular substrate impregnated with a visible-light photoinitiator with the foregoing electromagnetic radiation while the tubular substrate is disposed in an aqueous solution of a monomer, thereby initiating a radical polymerization of the monomer and coating the tubular substrate with the coating of the second polymer material.

公开(公告)号：US20240299629A1

公开(公告)日：2024-09-12

申请号：US18668479

申请日：2024-05-20

申请人： University of Georgia Research Foundation, Inc.

发明人： Hitesh Handa ,  Marcus Goudie

IPC分类号： A61L29/06 ,  A61L29/08 ,  A61L29/16 ,  C08J7/046 ,  C09D183/04

CPC分类号： A61L29/06 ,  A61L29/085 ,  A61L29/16 ,  C08J7/046 ,  C09D183/04 ,  A61L2300/114 ,  A61L2420/06

摘要： Embodiments of the present disclosure provide for treated articles of tubing having anti-fouling characteristics, methods of making treated articles of tubing, and the like. Disclosed herein are treated articles of tubing impregnated with a silicone oil and a nitric oxide release agent. Also described are methods for preparing a treated article of tubing and methods for delivering a pharmaceutically acceptable fluid to a subject in need thereof, wherein the fluid is transferred from a fluid source through treated articles of tubing to the subject.

公开(公告)号：US20240189553A1

公开(公告)日：2024-06-13

申请号：US18554937

申请日：2021-04-12

申请人： OrbusNeich Medical (Shenzhen) Co., Ltd.

发明人： Songyun XU ,  Lin WAN ,  Jingjing ZHU ,  Yirong GONG ,  Chang PENG ,  Mian LI ,  Xueying WEI

IPC分类号： A61M25/10 ,  A61L29/04 ,  A61L29/08 ,  A61L29/16

CPC分类号： A61M25/1029 ,  A61L29/049 ,  A61L29/085 ,  A61L29/16 ,  A61M25/104 ,  A61L2300/416 ,  A61L2300/608 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2025/1075

摘要： Balloon catheter (22) having a coating comprises a primer layer (24) comprising at least one or more substantially hydrophilic compounds, a first layer (26) comprising an inclusion compound; and a second layer (28) comprising a mixture of a hydrophobic polymer, an active therapeutic agent and the inclusion compound.

公开(公告)号：US20240181204A1

公开(公告)日：2024-06-06

申请号：US18284946

申请日：2022-03-31

申请人： FREEFLOW MEDICAL DEVICES LLC

发明人： Saibal BANDYOPADHYAY ,  Andrew K. JONES

IPC分类号： A61M25/00 ,  A61L29/08 ,  A61L29/14 ,  A61M1/36 ,  A61M27/00

CPC分类号： A61M25/0026 ,  A61L29/085 ,  A61L29/146 ,  A61M1/3661 ,  A61M27/006 ,  A61M25/0009 ,  A61M2025/0037 ,  A61M2025/0046

摘要： The present disclosure provides tubing comprising porous fluoropolymers for use in non-medical and medical applications along with methods of making the tubing. Also described are medical devices including catheters and shunts comprising the tubing. Specifically, a catheter, cannula, drain, shunt, or totally implantable venous access port comprising a section of tubing with at least two lumens separated by septa, as well as an outer wall and a fluorinated liquid. Wherein the outer wall and the septa are a porous fluoropolymer and the fluorinated liquid is absorbed into the pores of both the septa and the outer wall of the tubing.