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11 条记录 (耗时 0.026 秒)

    NITROGEN-CONTAINING BYCYCLIC COMPOUNDS ACTIVE ON CHRONIC PAIN CONDITIONS
    1.
    发明申请
    NITROGEN-CONTAINING BYCYCLIC COMPOUNDS ACTIVE ON CHRONIC PAIN CONDITIONS 有权
    含氯化合物在慢性疼痛症状中起主要作用

    公开(公告)号：US20110015200A1

    公开(公告)日：2011-01-20

    申请号：US12918718

    申请日：2009-02-17

    申请人： Carla Ghelardini ,  Marisa Martinelli ,  Carlo Parini ,  Silvano Ronzoni

    发明人： Carla Ghelardini ,  Marisa Martinelli ,  Carlo Parini ,  Silvano Ronzoni

    IPC分类号： A61K31/4985 ,  C07D487/04 ,  A61P19/02 ,  A61P25/00 ,  A61P29/00

    CPC分类号： C07D487/04 ,  C07D471/04

    摘要： The invention refers to compounds of general formula (I) wherein the R groups are, independently, H, C1-6alkyl, aryl, CF3; Y is CH2, C═O; X is bond, C═O, SO2, or C═N—CN; m is 0, 1; n is 0, 1; A is a heterocycle, or a phenyl group optionally substituted as defined in the specification. The compounds are active on chronic pain conditions of different origin; they can be administered alone or with other drugs. Most of these compounds are new. The invention include a process to prepare said compounds, and pharmaceutical compositions suitable for their administration to a patient.

    摘要翻译： 本发明涉及通式（I）的化合物，其中R基团独立地为H，C 1-6烷基，芳基，CF 3; Y是CH 2，C = O; X是键，C = O，SO 2或C = N-CN; m为0,1; n为0，1; A是杂环，或者如说明书中所定义的任选取代的苯基。 该化合物对不同来源的慢性疼痛病症有活性; 它们可以单独使用或与其他药物一起施用。 这些化合物大部分是新的。 本发明包括制备所述化合物的方法和适于给予患者的药物组合物。

    Substituted pyrrolo[1,2-A] pyrazines, compositions containing these, processes of making these, and uses thereof
    2.
    发明授权
    Substituted pyrrolo[1,2-A] pyrazines, compositions containing these, processes of making these, and uses thereof 有权
    取代的吡咯并[1,2-A]吡嗪，含有它们的组合物，制备方法及其用途

    公开(公告)号：US08334286B2

    公开(公告)日：2012-12-18

    申请号：US12918718

    申请日：2009-02-17

    申请人： Carla Ghelardini ,  Marisa Martinelli ,  Carlo Parini ,  Silvano Ronzoni

    发明人： Carla Ghelardini ,  Marisa Martinelli ,  Carlo Parini ,  Silvano Ronzoni

    IPC分类号： A61K31/495

    CPC分类号： C07D487/04 ,  C07D471/04

    摘要： The invention refers to compounds of general formula (I) wherein the R groups are, independently, H, C1-6alkyl, aryl, CF3; Y is CH2, C═O; X is bond, C═O, SO2, or C═N—CN; m is 0, 1; n is 0, 1; A is a heterocycle, or a phenyl group optionally substituted as defined in the specification. The compounds are active on chronic pain conditions of different origin; they can be administered alone or with other drugs. Most of these compounds are new. The invention include a process to prepare said compounds, and pharmaceutical compositions suitable for their administration to a patient.

    摘要翻译： 本发明涉及通式（I）的化合物，其中R基团独立地为H，C 1-6烷基，芳基，CF 3; Y是CH 2，C = O; X是键，C = O，SO 2或C = N-CN; m为0,1; n为0，1; A是杂环，或者如说明书中所定义的任选取代的苯基。 该化合物对不同来源的慢性疼痛病症有活性; 它们可以单独使用或与其他药物一起施用。 这些化合物大部分是新的。 本发明包括制备所述化合物的方法和适于给予患者的药物组合物。

    Quinoline Derivatives as NK-3 and NK-2 Antagonists
    7.
    发明申请
    Quinoline Derivatives as NK-3 and NK-2 Antagonists 审中-公开
    喹啉衍生物作为NK-3和NK-2拮抗剂

    公开(公告)号：US20070015766A1

    公开(公告)日：2007-01-18

    申请号：US11426414

    申请日：2006-06-26

    申请人： Carlo Farina ,  Stefania Gagliardi ,  Giuseppe Giardina ,  Mario Grugni ,  Marisa Martinelli ,  Guy Marguerite Marie Gerard Nadler

    发明人： Carlo Farina ,  Stefania Gagliardi ,  Giuseppe Giardina ,  Mario Grugni ,  Marisa Martinelli ,  Guy Marguerite Marie Gerard Nadler

    IPC分类号： A61K31/496 ,  C07D403/02

    CPC分类号： C07D401/12 ,  C07D215/52

    摘要： Certain compounds of formula (I) below or a pharmaceutically acceptable salt or hydrate thereof: wherein: R1 is H or alkyl; R2 is aryl, cycloalkyl or heteroaryl; R3 is H or C1-3 alkyl, optionally substituted by one or more fluorines; R4 is H, R8NR9R10, R11R13 or R11R12R13; or R5 is branched or linear alkyl, cycloalkyl, aryl, arylalkyl, or a single or fused ring aromatic heterocyclic group; a process for preparing such compounds, a pharmaceutical composition comprising such compounds and the use of such compounds and the use of such compounds and composition in medicine.

    摘要翻译： 某些下式（I）化合物或其药学上可接受的盐或水合物：其中：R 1是H或烷基; R 2是芳基，环烷基或杂芳基; R 3是H或C 1-3烷基，任选被一个或多个氟取代; R 4是H，R 8 NR 9 R 10，R 11 R 13或13个R 12 R 13 13; 或R 5是支链或直链烷基，环烷基，芳基，芳烷基或单或稠环芳族杂环基; 制备这些化合物的方法，包含这些化合物的药物组合物和这些化合物的用途以及这些化合物和组合物在医药中的用途。