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1.发明申请Indole and Azaindole Derivatives For the Treatment of Inflammatory and Autoimmune Diseases 审中-公开吲哚和Azaindole衍生物治疗炎症和自身免疫性疾病公开(公告)号：US20080226718A1
公开(公告)日：2008-09-18
申请号：US12091739
申请日：2006-10-25
IPC分类号： A61K9/28 , A61K31/404 , A61P17/06 , A61P37/00 , A61P1/00 , A61P19/02 , A61K31/5383
CPC分类号： A61K31/404
摘要： The use is described of compounds of formula (I) wherein A is chosen from a phenyl or a heterocyclic ring with 5 or 6 members containing up to two heteroatoms chosen from nitrogen, oxygen and sulfur, X and Y represent carbon or nitrogen, and R1-R6 are as described in the specification, in the prevention and/or treatment of inflammatory and autoimmune diseases.
摘要翻译： 描述了式（I）化合物，其中A选自苯基或杂环，其中5或6个成员含有至多两个选自氮，氧和硫的杂原子，X和Y表示碳或氮，R1 -R6如说明书中所述，在预防和/或治疗炎性和自身免疫疾病中。
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公开(公告)号：US20080317857A1
公开(公告)日：2008-12-25
申请号：US12091740
申请日：2006-10-27
IPC分类号： A61K9/28 , A61K31/7048 , A61K38/02 , A61K31/4015
CPC分类号： A61K31/4166 , A61K31/365 , A61K31/4015 , A61K31/7048
摘要： The use of vacuolar ATPase inhibitors in the prevention and/or treatment of septic shock is herein described. Vacuolar ATPase inhibitors are selected among products of natural, semi-synthetic or synthetic origin.
摘要翻译： 本文描述了液泡ATP酶抑制剂在预防和/或治疗败血性休克中的用途。 真空ATP酶抑制剂选自天然，半合成或合成来源的产品。
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公开(公告)号：US20100098714A1
公开(公告)日：2010-04-22
申请号：US12587879
申请日：2009-10-13
IPC分类号： A61K39/395 , A61P25/00
CPC分类号： A61K39/3955 , C07K16/2821 , C07K16/2836 , C07K16/2842 , C07K16/2845 , C07K16/2854 , C07K16/2896 , C07K2317/76
摘要： Methods are provided for the prevention and treatment of seizures and epilepsy. It is shown herein that leukocyte recruitment plays a key role in the pathogenesis of epilepsy. Treatment with an agent that inhibits leukocyte recruitment has therapeutic and preventative effects in blocking recurrent seizures and epilepsy.
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4.发明申请公开(公告)号：US20080025992A1
公开(公告)日：2008-01-31
申请号：US11811245
申请日：2007-06-06
IPC分类号： A61K39/395 , A61K45/00
CPC分类号： A61K39/3955 , C07K16/2821 , C07K16/2836 , C07K16/2842 , C07K16/2845 , C07K16/2854 , C07K16/2896 , C07K2317/76
摘要： Methods are provided for the prevention and treatment of seizures and epilepsy. It is shown herein that leukocyte recruitment plays a key role in the pathogenesis of epilepsy. Treatment with an agent that inhibits leukocyte recruitment has therapeutic and preventative effects in blocking recurrent seizures and epilepsy.
摘要翻译： 提供了预防和治疗癫痫发作和癫痫的方法。 这里显示白细胞募集在癫痫的发病机理中起关键作用。 用抑制白细胞募集的药物进行治疗具有阻止复发性癫痫发作和癫痫的治疗和预防作用。
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5.发明授权公开(公告)号：US08383116B2
公开(公告)日：2013-02-26
申请号：US12587879
申请日：2009-10-13
IPC分类号： A61K39/395 , A61K49/00 , C07K16/00
CPC分类号： A61K39/3955 , C07K16/2821 , C07K16/2836 , C07K16/2842 , C07K16/2845 , C07K16/2854 , C07K16/2896 , C07K2317/76
摘要： Methods are provided for the prevention and treatment of seizures and epilepsy. It is shown herein that leukocyte recruitment plays a key role in the pathogenesis of epilepsy. Treatment with an agent that inhibits leukocyte recruitment has therapeutic and preventative effects in blocking recurrent seizures and epilepsy.
摘要翻译： 提供了预防和治疗癫痫发作和癫痫的方法。 这里显示白细胞募集在癫痫的发病机理中起关键作用。 用抑制白细胞募集的药物进行治疗具有阻止复发性癫痫发作和癫痫的治疗和预防作用。
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6.发明授权公开(公告)号：US07682613B2
公开(公告)日：2010-03-23
申请号：US11811245
申请日：2007-06-06
IPC分类号： A61K39/395 , A61K49/00 , C07K16/00
CPC分类号： A61K39/3955 , C07K16/2821 , C07K16/2836 , C07K16/2842 , C07K16/2845 , C07K16/2854 , C07K16/2896 , C07K2317/76
摘要： Methods are provided for the prevention and treatment of seizures and epilepsy. It is shown herein that leukocyte recruitment plays a key role in the pathogenesis of epilepsy. Treatment with an agent that inhibits leukocyte recruitment has therapeutic and preventative effects in blocking recurrent seizures and epilepsy.
摘要翻译： 提供了预防和治疗癫痫发作和癫痫的方法。 这里显示白细胞募集在癫痫的发病机理中起关键作用。 用抑制白细胞募集的药物进行治疗具有阻止复发性癫痫发作和癫痫的治疗和预防作用。
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