公开(公告)号：US20060134767A1

公开(公告)日：2006-06-22

申请号：US10520492

申请日：2003-07-03

申请人： Carolyn Buser-Doepner ,  Paul Coleman ,  Christopher Cox ,  Mark Fraley ,  Robert Garbaccio ,  George Hartman ,  David Heimbrook ,  Lawrence Kuo ,  Hans Huber ,  Vinod Sardana ,  Maricel Torrent ,  Youwei Yan

发明人： Carolyn Buser-Doepner ,  Paul Coleman ,  Christopher Cox ,  Mark Fraley ,  Robert Garbaccio ,  George Hartman ,  David Heimbrook ,  Lawrence Kuo ,  Hans Huber ,  Vinod Sardana ,  Maricel Torrent ,  Youwei Yan

IPC分类号： C12N9/12 ,  G06F19/00

CPC分类号： C07K14/47 ,  C07K2299/00 ,  C12N9/14 ,  G01N33/6803 ,  G01N2500/04 ,  G16B15/00 ,  G16B20/00

摘要： The present invention is directed to the identification, characterization and three-dimensional structure of a novel ligand binding site of KSP. Binding of ligands to the novel binding site result in a conformational change in the three-dimensional structure of the protein and a modulation of the activity of KSP. This conformational change in turn results in the formation of a novel binding pocket in the KSP protein, which comprises the novel binding site of the instant invention.

摘要翻译： 本发明涉及KSP新型配体结合位点的鉴定，表征和三维结构。 配体与新结合位点的结合导致蛋白质三维结构的构象变化和KSP活性的调节。 这种构象变化又导致在KSP蛋白质中形成新的结合口袋，其包含本发明的新结合位点。