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    2, 3, 6 - TRIAMINO SUBSTITUTED PYRIDINES AS KV7 (KCNQ) CHANNEL MODULATORS
    5.
    发明申请
    2, 3, 6 - TRIAMINO SUBSTITUTED PYRIDINES AS KV7 (KCNQ) CHANNEL MODULATORS 审中-公开
    2，3，6 - 三咪唑替代吡啶作为KV7（KCNQ）通道调制器

    公开(公告)号：US20120238547A1

    公开(公告)日：2012-09-20

    申请号：US13394345

    申请日：2010-09-02

    申请人： William Dalby Brown ,  Carsten Jessen ,  Dorte Strøbæk

    发明人： William Dalby Brown ,  Carsten Jessen ,  Dorte Strøbæk

    IPC分类号： A61K31/553 ,  A61P25/18 ,  A61P25/24 ,  A61P25/22 ,  A61P25/06 ,  A61P9/12 ,  A61P13/10 ,  C07D413/14 ,  A61K31/5377 ,  A61P25/00 ,  A61P29/00 ,  A61P25/08

    CPC分类号： C07D413/14 ,  C07D405/14

    摘要： The present application relates to novel substituted aminopyridine derivatives, to their use in therapy, to pharmaceutical compositions comprising the derivatives, to the use of said derivatives in the manufacture of a medicament, and to therapeutic methods comprising the administration of the derivatives. The present derivatives are useful for treating a disorder responsive to activation of Kv7 channels. Due to the distribution of Kv7 channels within the organism, Kv7 channel modulators are considered potentially useful for the treatment or alleviation of conditions as diverse as CNS disorders, psychiatric disorders, CNS damage caused by trauma, stroke or neurodegenerative illness or diseases, a variety of neuronal hyperexcitability disorders and conditions, epilepsy, pain, neuropathic pain, migraine, tension type headache, learning and cognitive disorders, motion and motor disorders, multiple sclerosis, cardiac disorders, heart failure, cardio-myopathia, inflammatory diseases, ophthalmic conditions, deafness, progressive hearing loss, tinnitus, obstructive or inflammatory airway diseases, for inducing or maintaining bladder control including the treatment or prevention of urinary incontinence.

    摘要翻译： 本申请涉及用于治疗的新型取代的氨基吡啶衍生物，包含所述衍生物的药物组合物，所述衍生物在制备药物中的用途以及包括施用所述衍生物的治疗方法。 本发明的衍生物可用于治疗对Kv7通道的激活作出反应的病症。 由于Kv7通道在生物体内的分布，Kv7通道调节剂被认为可能用于治疗或缓解诸如CNS疾病，精神疾病，由创伤，中风或神经变性疾病或疾病引起的CNS损伤，各种各样的 神经元过度兴奋性疾病和病症，癫痫，疼痛，神经性疼痛，偏头痛，紧张型头痛，学习和认知障碍，运动和运动障碍，多发性硬化，心脏病，心力衰竭，心肌病，炎性疾病，眼科疾病，耳聋， 进行性听力损失，耳鸣，阻塞性或炎性气道疾病，用于诱导或维持膀胱控制，包括治疗或预防尿失禁。

    NOVEL 2-PYRROLIDINYL-3-AMIDO-6-AMINO-PYRIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL ACTIVATORS
    8.
    发明申请
    NOVEL 2-PYRROLIDINYL-3-AMIDO-6-AMINO-PYRIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL ACTIVATORS 审中-公开
    新型2-吡咯烷基-3-氨基-6-氨基 - 吡啶衍生物有效作为磷酸盐通道活化剂

    公开(公告)号：US20110039896A1

    公开(公告)日：2011-02-17

    申请号：US12747346

    申请日：2008-12-10

    申请人： William Dalby Brown ,  Carsten Jessen ,  Dorte Strøbæk

    发明人： William Dalby Brown ,  Carsten Jessen ,  Dorte Strøbæk

    IPC分类号： A61K31/4439 ,  C07D401/04 ,  A61P25/00

    CPC分类号： C07D213/75 ,  C07D405/12

    摘要： This invention relates to novel 2-pyrrolidinyl-3-amido-6-amino-pyridine derivatives having medical utility, to use of the 2-pyrrolidinyl-3-amido-6-amino-pyridine derivatives of the invention for the manufacture of a medicament, to pharmaceutical compositions comprising the 2-pyrrolidinyl-3-amido-6-amino-pyridine derivatives of the invention, and to methods of treating a disorder, disease or a condition of a subject, which disorder, disease or condition is responsive to activation of Kv7 channels.

    摘要翻译： 本发明涉及具有医学应用的新颖的2-吡咯烷基-3-氨基-6-氨基 - 吡啶衍生物，以使用本发明的2-吡咯烷基-3-氨基-6-氨基 - 吡啶衍生物来制备药物 涉及包含本发明的2-吡咯烷基-3-氨基-6-氨基 - 吡啶衍生物的药物组合物，以及治疗疾病，疾病或病症对受试者的病症，疾病或病症对活化有反应的方法 的Kv7通道。