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1.发明授权Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis 有权用于使用离子电渗法递送治疗剂（包括格拉司琼）的透皮系统公开(公告)号：US07856263B2
公开(公告)日：2010-12-21
申请号：US11112196
申请日：2005-04-22
CPC分类号： A61N1/30 , A61M2037/0007 , A61N1/0428 , A61N1/044
摘要： A disposable skin-worn device for the transdermal delivery at least one dose of charged therapeutic substances, including granisetron, by iontophoresis, the device comprising a donor reservoir containing an amount of a therapeutic substance to be delivered transdermally by iontophoresis, a counter reservoir, a source of electric power connected in a circuit between the donor reservoir and the counter reservoir and a control system for controlling current flow in the circuit to enable at least one dose of the therapeutic substance to be delivered transdermally by iontophoresis and wherein the control system includes a control element selected from the group consisting of a sensor activated by an external signal and a switch.
摘要翻译： 一种一次性皮肤佩戴的装置，用于透皮输送至少一个剂量的带电治疗物质，包括格拉司琼，通过离子电渗疗法，该装置包括供体储存器，该供体储存器含有通过离子电渗法透皮递送的治疗物质的量， 供电源连接在供体储存器和反向储存器之间的电路中，以及控制系统，用于控制电路中的电流流动，以使得至少一个剂量的治疗物质能够通过离子电渗疗法经皮递送，并且其中控制系统包括 从由外部信号激活的传感器和开关组成的组中选择的控制元件。
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2.发明授权Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis 有权用于使用离子电渗法递送治疗剂（包括格拉司琼）的透皮系统公开(公告)号：US08463373B2
公开(公告)日：2013-06-11
申请号：US12955043
申请日：2010-11-29
CPC分类号： A61N1/30 , A61M2037/0007 , A61N1/0428 , A61N1/044
摘要： A disposable skin-worn device for the transdermal delivery at least one dose of charged therapeutic substances, including granisetron, by iontophoresis, the device comprising a donor reservoir containing an amount of a therapeutic substance to be delivered transdermally by iontophoresis, a counter reservoir, a source of electric power connected in a circuit between the donor reservoir and the counter reservoir and a control system for controlling current flow in the circuit to enable at least one dose of the therapeutic substance to be delivered transdermally by iontophoresis and wherein the control system includes a control element selected from the group consisting of a sensor activated by an external signal and a switch.
摘要翻译： 一种一次性皮肤佩戴的装置，用于透皮输送至少一个剂量的带电治疗物质，包括格拉司琼，通过离子电渗疗法，该装置包括供体储存器，该供体储存器含有通过离子电渗法透皮递送的治疗物质的量， 供电源连接在供体储存器和反向储存器之间的电路中，以及控制系统，用于控制电路中的电流流动，以使得至少一个剂量的治疗物质能够通过离子电渗疗法经皮递送，并且其中控制系统包括 从由外部信号激活的传感器和开关组成的组中选择的控制元件。
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3.发明申请Transdermal Systems for the Delivery of Therapeutic Agents Including Granisetron Using Iontophoresis 有权用于使用离子电渗法包括格拉司琼的治疗剂递送的透皮系统公开(公告)号：US20110087154A1
公开(公告)日：2011-04-14
申请号：US12955043
申请日：2010-11-29
IPC分类号： A61N1/30
CPC分类号： A61N1/30 , A61M2037/0007 , A61N1/0428 , A61N1/044
摘要： A disposable skin-worn device for the transdermal delivery at least one dose of charged therapeutic substances, including granisetron, by iontophoresis, the device comprising a donor reservoir containing an amount of a therapeutic substance to be delivered transdermally by iontophoresis, a counter reservoir, a source of electric power connected in a circuit between the donor reservoir and the counter reservoir and a control system for controlling current flow in the circuit to enable at least one dose of the therapeutic substance to be delivered transdermally by iontophoresis and wherein the control system includes a control element selected from the group consisting of a sensor activated by an external signal and a switch.
摘要翻译： 一种一次性皮肤佩戴的装置，用于透皮输送至少一个剂量的带电治疗物质，包括格拉司琼，通过离子电渗疗法，该装置包括供体储存器，该供体储存器含有通过离子电渗法透皮递送的治疗物质的量， 供电源连接在供体储存器和反向储存器之间的电路中，以及控制系统，用于控制电路中的电流流动，以使得至少一个剂量的治疗物质能够通过离子电渗疗法经皮递送，并且其中控制系统包括 从由外部信号激活的传感器和开关组成的组中选择的控制元件。
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公开(公告)号：US07031768B2
公开(公告)日：2006-04-18
申请号：US10166157
申请日：2002-06-10
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/044 , A61N1/0448
摘要： A planar disposable transdermal iontophoretic delivery system is disclosed which includes amounts of an oxidizable species and a reducible species connected by a common conductor forming a galvanic battery for serving as the sole source of power and control for the system, an amount of a therapeutic agent is provided to be driven through the skin of a patient solely through the use of the galvanic battery. The galvanic battery is provided with a lot-tested coulombic capacity rating to predict dosage.
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5.发明申请Transdermal Methods and Systems for the Delivery of Corticosteroid Compounds 有权用于皮质类固醇化合物递送的透皮方法和系统公开(公告)号：US20090062720A1
公开(公告)日：2009-03-05
申请号：US12199051
申请日：2008-08-27
CPC分类号： A61N1/0448 , A61K9/0009 , A61N1/044
摘要： An integrated iontophoresis skin-worn patch and method for delivering a therapeutically effective amount of a corticosteroid drug compound in a systemically-safe and skin-safe manner for site-specific treatment of inflammation pain is disclosed.
摘要翻译： 公开了一种用于以系统安全和皮肤安全的方式递送治疗有效量的皮质类固醇药物化合物的综合离子电渗皮肤磨损贴片和方法，用于炎症疼痛的特异性治疗。
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6.发明授权Transdermal methods and systems for the delivery of corticosteroid compounds 有权用于输送皮质类固醇化合物的透皮方法和系统公开(公告)号：US09421356B2
公开(公告)日：2016-08-23
申请号：US12199051
申请日：2008-08-27
CPC分类号： A61N1/0448 , A61K9/0009 , A61N1/044
摘要： An integrated iontophoresis skin-worn patch and method for delivering a therapeutically effective amount of a corticosteroid drug compound in a systemically-safe and skin-safe manner for site-specific treatment of inflammation pain is disclosed.
摘要翻译： 公开了一种用于以系统安全和皮肤安全的方式递送治疗有效量的皮质类固醇药物化合物的综合离子电渗皮肤磨损贴片和方法，用于炎症疼痛的特异性治疗。
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7.发明授权Transdermal systems for the delivery of ionic agents directly to open wounds and surgically repaired incisions 有权用于将离子剂直接递送至开放性伤口和手术修复的切口的透皮系统公开(公告)号：US08295924B2
公开(公告)日：2012-10-23
申请号：US13009999
申请日：2011-01-20
CPC分类号： A61N1/0448
摘要： A transdermal system for the delivery of an anesthetic or other active therapeutic agent directly to a selected site of injured skin tissue by iontophoresis is disclosed, which utilizes a transdermal skin-worn patch including a donor electrode chamber containing a donor electrode and an amount of an active agent in a form suitable for transdermal delivery in electrical communication with the donor electrode and a return electrode. The patch also contains a source of electric current connected in a circuit with the donor and return electrode, a current regulating device is optionally provided in the circuit for controlling the electrical output of the patch and at least the donor electrode chamber includes a provision for absorbing a quantity of fluid associated with weepage from adjacent injured skin tissue.
摘要翻译： 公开了一种用于通过离子电渗法将麻醉剂或其它活性治疗剂直接递送至受损皮肤组织的选定部位的透皮系统，其利用透皮的皮肤佩戴的贴片，其包括供体电极室，其包含施主电极和 活性剂，其形式适合于与供体电极和返回电极电连通的透皮递送。 贴片还包含与供体和返回电极在电路中连接的电流源，电路中可选地提供电流调节装置，用于控制贴片的电输出，并且至少供体电极室包括用于吸收 与来自相邻受伤皮肤组织的渗漏相关的一定量的流体。
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8.发明申请Transdermal Systems for the Delivery of Ionic Agents Directly to Open Wounds and Surgically Repaired Incisions 有权透皮系统用于直接输送离子代谢物以开放伤口和手术修复切口公开(公告)号：US20110112465A1
公开(公告)日：2011-05-12
申请号：US13009999
申请日：2011-01-20
IPC分类号： A61N1/30
CPC分类号： A61N1/0448
摘要： A transdermal system for the delivery of an anesthetic or other active therapeutic agent directly to a selected site of injured skin tissue by iontophoresis is disclosed, which utilizes a transdermal skin-worn patch including a donor electrode chamber containing a donor electrode and an amount of an active agent in a form suitable for transdermal delivery in electrical communication with the donor electrode and a return electrode. The patch also contains a source of electric current connected in a circuit with the donor and return electrode, a current regulating device is optionally provided in the circuit for controlling the electrical output of the patch and at least the donor electrode chamber includes a provision for absorbing a quantity of fluid associated with weepage from adjacent injured skin tissue.
摘要翻译： 公开了一种用于通过离子电渗法将麻醉剂或其它活性治疗剂直接递送至受损皮肤组织的选定部位的透皮系统，其利用透皮的皮肤佩戴的贴片，其包括供体电极室，其包含施主电极和 活性剂，其形式适合于与供体电极和返回电极电连通的透皮递送。 贴片还包含与供体和返回电极在电路中连接的电流源，电路中可选地提供电流调节装置，用于控制贴片的电输出，并且至少供体电极室包括用于吸收 与来自相邻受伤皮肤组织的渗漏相关的一定量的流体。
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9.发明授权Transdermal systems for the delivery of ionic agents directly to open wounds and surgically repaired incisions 有权用于将离子剂直接递送至开放性伤口和手术修复的切口的透皮系统公开(公告)号：US07904146B2
公开(公告)日：2011-03-08
申请号：US11937769
申请日：2007-11-09
CPC分类号： A61N1/0448
摘要： A transdermal system for the delivery of an anesthetic or other active therapeutic agent directly to a selected site of injured skin tissue by iontophoresis is disclosed, which utilizes a transdermal skin-worn patch including a donor electrode chamber containing a donor electrode and an amount of an active agent in a form suitable for transdermal delivery in electrical communication with the donor electrode and a return electrode. The patch also contains a source of electric current connected in a circuit with the donor and return electrode, a current regulating device is optionally provided in the circuit for controlling the electrical output of the patch and at least the donor electrode chamber includes a provision for absorbing a quantity of fluid associated with weepage from adjacent injured skin tissue.
摘要翻译： 公开了一种用于通过离子电渗法将麻醉剂或其它活性治疗剂直接递送至受损皮肤组织的选定部位的透皮系统，其利用透皮的皮肤佩戴的贴片，其包括供体电极室，其包含施主电极和 活性剂，其形式适合于与供体电极和返回电极电连通的透皮递送。 贴片还包含与供体和返回电极在电路中连接的电流源，电路中可选地提供电流调节装置，用于控制贴片的电输出，并且至少供体电极室包括用于吸收 与来自相邻受伤皮肤组织的渗漏相关的一定量的流体。
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10.发明申请Transdermal Systems for the Delivery of Ionic Agents Directly to Open Wounds and Surgically Repaired Incisions 有权透皮系统用于直接输送离子代谢物以开放伤口和手术修复切口公开(公告)号：US20080114284A1
公开(公告)日：2008-05-15
申请号：US11937769
申请日：2007-11-09
IPC分类号： A61N1/30
CPC分类号： A61N1/0448
摘要： A transdermal system for the delivery of an anesthetic or other active therapeutic agent directly to a selected site of injured skin tissue by iontophoresis is disclosed, which utilizes a transdermal skin-worn patch including a donor electrode chamber containing a donor electrode and an amount of an active agent in a form suitable for transdermal delivery in electrical communication with the donor electrode and a return electrode. The patch also contains a source of electric current connected in a circuit with the donor and return electrode, a current regulating device is optionally provided in the circuit for controlling the electrical output of the patch and at least the donor electrode chamber includes a provision for absorbing a quantity of fluid associated with weepage from adjacent injured skin tissue.
摘要翻译： 公开了一种用于通过离子电渗法将麻醉剂或其它活性治疗剂直接递送至受损皮肤组织的选定部位的透皮系统，其利用透皮的皮肤佩戴的贴片，其包括供体电极室，其包含施主电极和 活性剂，其形式适合于与供体电极和返回电极电连通的透皮递送。 贴片还包含与供体和返回电极在电路中连接的电流源，电路中可选地提供电流调节装置，用于控制贴片的电输出，并且至少供体电极室包括用于吸收 与来自相邻受伤皮肤组织的渗漏相关的一定量的流体。
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