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公开(公告)号：US07510844B2
公开(公告)日：2009-03-31
申请号：US11656206
申请日：2007-01-22
IPC分类号： G01N33/53
CPC分类号： C07K16/2827 , G01N33/5047 , G01N33/505 , G01N2333/70532 , G01N2800/245 , Y10S530/809
摘要： The present invention discloses a method for assaying the binding of L104EA29YIg to a receptor. The receptor is preferably CD86 or CD80. The present invention also discloses antibodies to be used in the assay, as well as hybridomas expressing the antibodies.
摘要翻译： 本发明公开了一种测定L104EA29YIg与受体结合的方法。 受体优选为CD86或CD80。 本发明还公开了用于测定中的抗体，以及表达抗体的杂交瘤。
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公开(公告)号：US20120077207A1
公开(公告)日：2012-03-29
申请号：US12319442
申请日：2009-01-07
IPC分类号： G01N33/566 , C12N5/16 , C07K16/28
CPC分类号： C07K16/2827 , G01N33/5047 , G01N33/505 , G01N2333/70532 , G01N2800/245 , Y10S530/809
摘要： The present invention discloses a method for assaying the binding of L104EA29YIg to a receptor. The receptor is preferably CD86 or CD80. The present invention also discloses antibodies to be used in the assay, as well as hybridomas expressing the antibodies.
摘要翻译： 本发明公开了一种测定L104EA29YIg与受体结合的方法。 受体优选为CD86或CD80。 本发明还公开了用于测定中的抗体以及表达抗体的杂交瘤。
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公开(公告)号：US08378082B2
公开(公告)日：2013-02-19
申请号：US12319442
申请日：2009-01-07
CPC分类号： C07K16/2827 , G01N33/5047 , G01N33/505 , G01N2333/70532 , G01N2800/245 , Y10S530/809
摘要： The present invention discloses a method for assaying the binding of L104EA29YIg to a receptor. The receptor is preferably CD86 or CD80. The present invention also discloses antibodies to be used in the assay, as well as hybridomas expressing the antibodies.
摘要翻译： 本发明公开了一种测定L104EA29YIg与受体结合的方法。 受体优选为CD86或CD80。 本发明还公开了用于测定中的抗体以及表达抗体的杂交瘤。
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4.发明授权Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK) 失效使用IkappaB激酶抑制剂（IKK）治疗炎症和免疫疾病的方法公开(公告)号：US06869956B2
公开(公告)日：2005-03-22
申请号：US10062847
申请日：2002-02-01
IPC分类号： A61K31/4985 , A61K31/519 , A61P1/00 , A61P11/06 , A61P19/02 , A61P37/06 , C07D471/04 , C07D487/04 , C07D513/04
CPC分类号： C07D471/04 , A61K31/4985 , A61K31/519 , C07D487/04 , C07D513/04
摘要： The present invention describes methods of preventing and treating inflammatory and immune-related diseases or disorders using inhibitors of IκB kinase (IKK). Also described are IKK inhibitors effective for the prevention and treatment of inflammatory and immune-related diseases or disorders, as demonstrated in vivo. Further embodiments of the present invention relate to a specific IKK inhibitors, 4(2′-aminoethyl)amino-1,8-dimethylimidazo(1,2-a) quinoxaline and compounds of formula (I), salts thereof, and pharmaceutical compositions.
摘要翻译： 本发明描述了使用IkappaB激酶（IKK）抑制剂预防和治疗炎性和免疫相关疾病或病症的方法。 还描述了如体内所证明的有效预防和治疗炎性和免疫相关疾病或病症的IKK抑制剂。 本发明的其它实施方案涉及特定的IKK抑制剂，4（2'-氨基乙基）氨基-1,8-二甲基咪唑（1,2-a）喹喔啉和式（I）化合物，其盐和药物组合物。
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