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公开(公告)号：US20150284308A1
公开(公告)日：2015-10-08
申请号：US14646198
申请日：2013-11-21
发明人： Catherine F. Yang , Weixing Li , Ryan Elliott , Nikita Iltchencko
CPC分类号： C07C35/14 , A61K36/22 , A61K2236/00 , B01D11/02 , B01D11/0288
摘要： The disclosure relates to methods for preparing urushiol from plants including, for example, poison ivy or poison oak. The methods include extraction of plant material using a primary organic solvent more polar than ethanol, followed by a solvent extraction using substantially immiscible solvents having substantially different polarities, such as hexane and acetonitrile. The method can include further purification, such as by fractionation of solvent-extracted materials using a thiazole-derivatized silica gel chromatography medium. The extracts thus generated can exhibit greater purity, higher concentration, and greater stability than extracts made using previously-known methods. The extracts can be particularly suitable for use in immunotherapeutic methods, such as desensitizing individuals who normally develop allergic contact dermatitis attributable to poison ivy or poison oak.
摘要翻译： 本公开涉及从植物制备漆酚的方法，包括例如毒藤或毒栎。 所述方法包括使用比乙醇更极性的主要有机溶剂提取植物材料，然后使用基本上不相溶的溶剂（其具有基本上不同的极性，例如己烷和乙腈）进行溶剂萃取。 该方法可以包括进一步纯化，例如通过使用噻唑衍生的硅胶色谱介质对溶剂萃取物进行分级分离。 由此产生的提取物可以表现出比使用先前已知方法制备的提取物更高的纯度，更高的浓度和更高的稳定性。 提取物可以特别适用于免疫治疗方法，例如通常发生归因于毒藤或毒栎的过敏性接触性皮炎的个体脱敏。
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2.发明申请公开(公告)号：US20200222531A1
公开(公告)日：2020-07-16
申请号：US16664849
申请日：2019-10-26
摘要： Provided herein are methods of populating a target tissue of interest of a subject with precipitated particles of a modified or synthesized substance of interest, in which tissue the precipitated particles remain where they are formed for a sufficient time to begin their interaction with the physiology of the recipient in the physical state and locations in which they were formed, when the unmodified/unsynthesized form of the substance does not innately have the requisite solubility properties to be delivered to such tissues within the body of a designated target tissue by precipitation. The present methods include precipitating particles of the modified or synthesized substance within the target tissue by administering a solution to the target tissue of interest of a subject. The solution includes a pharmaceutically acceptable, water-miscible, non-aqueous solvent that is freely miscible with tissue fluids of the target tissue; and the modified or synthesized substance of interest, which is modified or synthesized to confer the presently required solubility properties of being soluble in the solvent and insoluble in tissue fluids of the target tissue of interest.
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公开(公告)号：US09580373B2
公开(公告)日：2017-02-28
申请号：US14646198
申请日：2013-11-21
申请人： Rowan University
发明人： Catherine F. Yang , Weixing Li , Ryan Elliot , Nikita Iltchenko
CPC分类号： C07C35/14 , A61K36/22 , A61K2236/00 , B01D11/02 , B01D11/0288
摘要： The disclosure relates to methods for preparing urushiol from plants including, for example, poison ivy or poison oak. The methods include extraction of plant material using a primary organic solvent more polar than ethanol, followed by a solvent extraction using substantially immiscible solvents having substantially different polarities, such as hexane and acetonitrile. The method can include further purification, such as by fractionation of solvent-extracted materials using a thiazole-derivatized silica gel chromatography medium. The extracts thus generated can exhibit greater purity, higher concentration, and greater stability than extracts made using previously-known methods. The extracts can be particularly suitable for use in immunotherapeutic methods, such as desensitizing individuals who normally develop allergic contact dermatitis attributable to poison ivy or poison oak.
摘要翻译： 本公开涉及从植物制备漆酚的方法，包括例如毒藤或毒栎。 所述方法包括使用比乙醇更极性的主要有机溶剂提取植物材料，然后使用基本上不相溶的溶剂（其具有基本上不同的极性，例如己烷和乙腈）进行溶剂萃取。 该方法可以包括进一步纯化，例如通过使用噻唑衍生的硅胶色谱介质对溶剂萃取物进行分级分离。 由此产生的提取物可以表现出比使用先前已知方法制备的提取物更高的纯度，更高的浓度和更高的稳定性。 提取物可以特别适用于免疫治疗方法，例如通常发生归因于毒藤或毒栎的过敏性接触性皮炎的个体脱敏。
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