公开(公告)号：US07199121B2

公开(公告)日：2007-04-03

申请号：US10363914

申请日：2001-09-07

申请人： Catherine J. Pallen ,  Haishan Wang ,  Kah Leong Lim ,  Su Ling Yeo ,  Yue Wang ,  Yin Hwee Tan

发明人： Catherine J. Pallen ,  Haishan Wang ,  Kah Leong Lim ,  Su Ling Yeo ,  Yue Wang ,  Yin Hwee Tan

IPC分类号： C07D487/04 ,  A61K31/53 ,  A61P35/00 ,  A61P31/10

CPC分类号： C07D487/04 ,  A61K31/53 ,  C12P17/182 ,  C12R1/465

摘要： Use of a compound of formula (I): wherein each R, which are the same or different, is H or C1–C6 alkyl, and X completes a ring which is a substituted triazine having one of the following formulae (II) to (IV): wherein R′ is H or C1–C6 alkyl; or an enol tautomer of a compound of formula (I) in which any of the groups R or R′ is hydrogen; in the manufacture of a medicament for use as a protein tyrosine phosphatase (PTP) inhibitor. Formula (I) embraces 2-methylfervenulone, which can be produced by fermentation of a novel microbial strain. Fermentation of the said strain also produces novel precursors to 2-methylfervenulone having utility as prodrugs.

摘要翻译： 式（I）化合物的用途：