公开(公告)号：US20220095608A1

公开(公告)日：2022-03-31

申请号：US17548450

申请日：2021-12-10

Applicant: Cell Cure Neurosciences Ltd.

Inventor： Nir NETZER ,  Ofer WISER ,  Bat SHAHAF ,  Orit GAMBURG ,  Lior ROSENBERG BELMAKER ,  Dana HAYOUN NEEMAN ,  Osnat BOHANA KASHTAN

IPC: A01N1/02 ,  A61K9/00 ,  A61K35/30 ,  A61K47/02 ,  A61K47/18 ,  A61K47/20 ,  A61K47/26

Abstract: Presented herein are ready to administer (RTA) retinal pigment epithelium (RPE) cell therapy compositions for the treatment of retinal degenerative diseases and injuries. A method of formulating human RPE cells for administration to a subject directly after thawing and of formulating RPE cell therapy compositions for cryopreservation and administration of the cryopreserved composition to a subject subsequent to thawing are also presented. In another aspect, the RTA composition may be formulated as a thaw and inject (TAI) composition, whereby the composition is administered by injection subsequent to thawing.

公开(公告)号：US20210000102A1

公开(公告)日：2021-01-07

申请号：US16958399

申请日：2018-12-28

Applicant: Cell Cure Neurosciences Ltd.

Inventor： Nir NETZER ,  Ofer WISER ,  Bat SHAHAF ,  Orit GAMBURG ,  Lior ROSENBERG BELMAKER ,  Dana HAYOUN NEEMAN ,  Osnat BOHANA KASHTAN

IPC: A01N1/02 ,  A61K35/30 ,  A61K9/00 ,  A61K47/02 ,  A61K47/26 ,  A61K47/18 ,  A61K47/20

Abstract: Presented herein are ready to administer (RTA) retinal pigment epithelium (RPE) cell therapy compositions for the treatment of retinal degenerative diseases and injuries. A method of formulating human RPE cells for administration to a subject directly after thawing and of formulating RPE cell therapy compositions for cryopreservation and administration of the cryopreserved composition to a subject subsequent to thawing are also presented. In another aspect, the RTA composition may be formulated as a thaw and inject (TAI) composition, whereby the composition is administered by injection subsequent to thawing.