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Patent Agency Ranking
公开(公告)号：US20210000102A1
公开(公告)日：2021-01-07
申请号：US16958399
申请日：2018-12-28
Applicant: Cell Cure Neurosciences Ltd.
Inventor： Nir NETZER , Ofer WISER , Bat SHAHAF , Orit GAMBURG , Lior ROSENBERG BELMAKER , Dana HAYOUN NEEMAN , Osnat BOHANA KASHTAN
Abstract: Presented herein are ready to administer (RTA) retinal pigment epithelium (RPE) cell therapy compositions for the treatment of retinal degenerative diseases and injuries. A method of formulating human RPE cells for administration to a subject directly after thawing and of formulating RPE cell therapy compositions for cryopreservation and administration of the cryopreserved composition to a subject subsequent to thawing are also presented. In another aspect, the RTA composition may be formulated as a thaw and inject (TAI) composition, whereby the composition is administered by injection subsequent to thawing.
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公开(公告)号：US20220095608A1
公开(公告)日：2022-03-31
申请号：US17548450
申请日：2021-12-10
Applicant: Cell Cure Neurosciences Ltd.
Inventor： Nir NETZER , Ofer WISER , Bat SHAHAF , Orit GAMBURG , Lior ROSENBERG BELMAKER , Dana HAYOUN NEEMAN , Osnat BOHANA KASHTAN
Abstract: Presented herein are ready to administer (RTA) retinal pigment epithelium (RPE) cell therapy compositions for the treatment of retinal degenerative diseases and injuries. A method of formulating human RPE cells for administration to a subject directly after thawing and of formulating RPE cell therapy compositions for cryopreservation and administration of the cryopreserved composition to a subject subsequent to thawing are also presented. In another aspect, the RTA composition may be formulated as a thaw and inject (TAI) composition, whereby the composition is administered by injection subsequent to thawing.
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公开(公告)号：US20190137482A1
公开(公告)日：2019-05-09
申请号：US16242023
申请日：2019-01-08
Inventor： Talya MORDECHAI DANIEL , Ofer WISER , Benjamin Eithan REUBINOFF
IPC: G01N33/50
Abstract: A method of determining whether an agent is a neuroeffector is disclosed. The method comprises: (a) labeling dopaminergic neurons which are comprised in a mixed population of cells with a fluorescent dopamine analog; (b) measuring a level of fluorescence in the mixed population of cells; (c) exposing the mixed population of cells to the agent; (d) remeasuring a level of fluorescence in the mixed population of cells, wherein a change in the level of fluorescence is indicative of the substance being a neuroeffector.
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公开(公告)号：US20180312805A1
公开(公告)日：2018-11-01
申请号：US15771046
申请日：2016-10-26
Inventor： Benjamin Eithan REUBINOFF , Orna SINGER , Osnat BOHANA-KASHTAN , Ofer WISER
IPC: C12N5/079 , C12N5/0735 , C12N5/00
CPC classification number: C12N5/0621 , C12N2501/15 , C12N2501/16 , C12N2506/02 , C12N2533/52
Abstract: A method of generating retinal pigment epithelium cells is disclosed. Cell populations comprising same and uses thereof are also disclosed.
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公开(公告)号：US20150377864A1
公开(公告)日：2015-12-31
申请号：US14766784
申请日：2014-02-12
Inventor： Talya MORDECHAI DANIEL , Ofer WISER , Benjamin Eithan REUBINOFF
IPC: G01N33/50
CPC classification number: G01N33/5058 , G01N33/502 , G01N2333/70571
Abstract: A method of determining whether an agent is a neuroeffector is disclosed. The method comprises: (a) labeling dopaminergic neurons which are comprised in a mixed population of cells with a fluorescent dopamine analog; (b) measuring a level of fluorescence in the mixed population of cells; (c) exposing the mixed population of cells to the agent; (d) remeasuring a level of fluorescence in the mixed population of cells, wherein a change in the level of fluorescence is indicative of the substance being a neuroeffector.
Abstract translation: 公开了一种确定药剂是否是神经递质的方法。 该方法包括：（a）将含有荧光多巴胺类似物的混合细胞群中的多巴胺能神经元标记; （b）测量混合细胞群体中的荧光水平; （c）将混合的细胞群暴露于所述试剂; （d）重新测量混合细胞群体中的荧光水平，其中荧光水平的变化指示物质是神经递质。
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