公开(公告)号：US10941201B2

公开(公告)日：2021-03-09

申请号：US16986613

申请日：2020-08-06

申请人： Celldex Therapeutics, Inc.

发明人： Tibor Keler ,  Joel Goldstein ,  Laura A. Vitale ,  Lizhen He ,  Tom O'Neill ,  Andrea Crocker ,  Karuna Sundarapandiyan ,  Lawrence J. Thomas ,  Jenifer Widger

IPC分类号： A61K39/395 ,  C07K16/28 ,  C07K14/54 ,  C07K14/715 ,  C07K14/705 ,  A61K39/00

摘要： Isolated monoclonal agonistic antibodies which bind to human CD40 and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.

公开(公告)号：US20220177593A1

公开(公告)日：2022-06-09

申请号：US17598005

申请日：2020-03-27

申请人： Celldex Therapeutics, Inc.

发明人： Tibor Keler ,  Diego Alvarado ,  Richard W. Gedrich ,  Joel Goldstein ,  Laura Vitale ,  Thomas O'Neill ,  Andrea Crocker ,  Jenifer Widger ,  Michael B. Murphy ,  Shannon Pankratz

IPC分类号： C07K16/28

摘要： Provided herein are compositions, methods and uses involving antibodies that specifically bind to Axl, a receptor tyrosine kinase. Also provided are uses and methods for managing, treating, or preventing disorders, such as cancer using the anti-Axl antibodies.

公开(公告)号：US20180066053A1

公开(公告)日：2018-03-08

申请号：US15490589

申请日：2017-04-18

申请人： Celldex Therapeutics, Inc.

发明人： Tibor KELER ,  Joel GOLDSTEIN ,  Laura A. VITALE ,  Lizhen HE ,  Tom O'NEILL ,  Andrea CROCKER ,  Karuna SUNDARAPANDIYAN ,  Lawrence J. THOMAS ,  Jenifer Widger

IPC分类号： C07K16/28 ,  C07K14/715 ,  C07K14/54

CPC分类号： C07K16/2803 ,  A61K39/39541 ,  A61K2039/505 ,  C07K14/54 ,  C07K14/70575 ,  C07K14/715 ,  C07K16/2878 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/92 ,  A61K2300/00

摘要： Isolated monoclonal agonistic antibodies which bind to human CD40 and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.