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公开(公告)号：US10793639B2
公开(公告)日：2020-10-06
申请号：US16214980
申请日：2018-12-10
发明人： Yaron Hadari , Elizabeth M. Mandel-Bausch , Susanne Radke , Joseph Schlessinger , Yoshihisa Suzuki
IPC分类号： A61K39/395 , C07K16/28 , A61K47/68 , C12N9/24 , G01N33/68 , A61K45/06 , G01N33/573 , A61K39/00
摘要： Provided herein, in one aspect, are antibodies that immunospecifically bind to a human KIT antigen comprising the fourth and/or fifth extracellular Ig-like domains (that is, D4 and/or D5 domains), polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. The antibodies can inhibit KIT activity, such as ligand-induced receptor phosphorylation. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to a KIT antigen, as well as methods of treating or managing a KIT-mediated disorder or disease and methods of diagnosing a KIT-mediated disorder or disease using the antibodies described herein.
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公开(公告)号：US20190100598A1
公开(公告)日：2019-04-04
申请号：US16214980
申请日：2018-12-10
发明人： Yaron Hadari , Elizabeth M. Mandel-Bausch , Susanne Radke , Joseph Schlessinger , Yoshihisa Suzuki
IPC分类号： C07K16/28 , A61K39/395 , A61K47/68 , G01N33/68 , G01N33/573 , A61K45/06 , C12N9/24 , A61K39/00
摘要： Provided herein, in one aspect, are antibodies that immunospecifically bind to a human KIT antigen comprising the fourth and/or fifth extracellular Ig-like domains (that is, D4 and/or D5 domains), polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. The antibodies can inhibit KIT activity, such as ligand-induced receptor phosphorylation. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to a KIT antigen, as well as methods of treating or managing a KIT-mediated disorder or disease and methods of diagnosing a KIT-mediated disorder or disease using the antibodies described herein.
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公开(公告)号：US20240141063A1
公开(公告)日：2024-05-02
申请号：US18538698
申请日：2023-12-13
发明人： Yaron Hadari , Elizabeth M. Mandel-Bausch , Susanne Radke , Joseph Schlessinger , Yoshihisa Suzuki
IPC分类号： C07K16/28 , A61K39/395 , A61K45/06 , A61K47/68 , C12N9/24 , G01N33/573 , G01N33/68
CPC分类号： C07K16/2896 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K47/6817 , A61K47/6849 , C07K16/2803 , C12N9/2497 , G01N33/573 , G01N33/6854 , A61K2039/505
摘要： Provided herein, in one aspect, are antibodies that immunospecifically bind to a human KIT antigen comprising the fourth and/or fifth extracellular Ig-like domains (that is, D4 and/or D5 domains), polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. The antibodies can inhibit KIT activity, such as ligand-induced receptor phosphorylation. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to a KIT antigen, as well as methods of treating or managing a KIT-mediated disorder or disease and methods of diagnosing a KIT-mediated disorder or disease using the antibodies described herein.
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公开(公告)号：US11884699B2
公开(公告)日：2024-01-30
申请号：US16994164
申请日：2020-08-14
发明人： Yaron Hadari , Elizabeth M. Mandel-Bausch , Susanne Radke , Joseph Schlessinger , Yoshihisa Suzuki
IPC分类号： C07K16/28 , A61K47/68 , A61K39/395 , C12N9/24 , G01N33/68 , A61K45/06 , G01N33/573 , A61K39/00
CPC分类号： C07K16/2896 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K47/6817 , A61K47/6849 , C07K16/2803 , C12N9/2497 , G01N33/573 , G01N33/6854 , A61K2039/505 , C07K2317/24 , C07K2317/30 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N2333/912
摘要： Provided herein, in one aspect, are antibodies that immunospecifically bind to a human KIT antigen comprising the fourth and/or fifth extracellular Ig-like domains (that is, D4 and/or D5 domains), polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. The antibodies can inhibit KIT activity, such as ligand-induced receptor phosphorylation. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to a KIT antigen, as well as methods of treating or managing a KIT-mediated disorder or disease and methods of diagnosing a KIT-mediated disorder or disease using the antibodies described herein.
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公开(公告)号：US10189907B2
公开(公告)日：2019-01-29
申请号：US15361936
申请日：2016-11-28
IPC分类号： C12N15/13 , C12N15/09 , C12N15/11 , C12N15/12 , C07K16/28 , A61K39/395 , C12N9/24 , G01N33/68 , A61K45/06 , G01N33/573 , A61K47/68 , A61K39/00
摘要： Provided herein, in one aspect, are antibodies that immunospecifically bind to a human KIT antigen comprising the fourth and/or fifth extracellular Ig-like domains (that is, D4 and/or D5 domains), polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. The antibodies can inhibit KIT activity, such as ligand-induced receptor phosphorylation. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to a KIT antigen, as well as methods of treating or managing a KIT-mediated disorder or disease and methods of diagnosing a KIT-mediated disorder or disease using the antibodies described herein.
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