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公开(公告)号：US09619881B2
公开(公告)日：2017-04-11
申请号：US14492385
申请日：2014-09-22
申请人： Cellogy, Inc.
CPC分类号： G06T7/0012 , G06K9/00147 , G06T7/0016 , G06T7/11 , G06T7/143 , G06T7/60 , G06T2207/20081 , G06T2207/30024
摘要： A method and system for characterizing a cell population including a set of cell subpopulations, the method comprising: at a processing system, receiving image data corresponding to a set of images of the cell population captured at a set of time points; at the processing system, generating an analysis based upon processing the set of images according to: a cell stage classification module configured to automatically identify a cell class of each of the set of cell subpopulations, and a cell graph representation module configured to characterize geometric and spatial features of the set of cell subpopulations; from the analysis, determining a set of parameters characterizing the cell population; and generating an indication of quality of the cell population based upon a comparison between at least one parameter of the set of parameters and a set of reference values.
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公开(公告)号：US09569845B2
公开(公告)日：2017-02-14
申请号：US15140745
申请日：2016-04-28
申请人： Cellogy, Inc.
CPC分类号： G06T7/0016 , G06K9/0014 , G06K9/6215 , G06T7/20 , G06T7/215 , G06T7/246 , G06T2207/10016 , G06T2207/30004 , G06T2207/30024 , G06T2207/30048
摘要： A method and system for characterizing cell motion comprising: receiving image data corresponding to a set of images of a cell culture captured at a set of time points; segmenting, from at least one image of the set of images, a cell subpopulation from the cell culture; determining a resting signal for the cell subpopulation; determining a single-peak motion signal based upon the set of images, the set of time points, and the resting signal; detrending the single-peak motion signal of the cell subpopulation based upon the resting signal; determining values of a set of motion features of the cell subpopulation, thereby characterizing cell motion; and clustering the cell subpopulation with at least one other cell subpopulation based upon at least one of the single-peak motion signal and a value of the set of motion features.
摘要翻译： 一种用于表征细胞运动的方法和系统，包括：接收与在一组时间点捕获的细胞培养物的一组图像相对应的图像数据; 从所述图像集合中的至少一个图像分割来自所述细胞培养物的细胞亚群; 确定细胞亚群的静息信号; 基于所述图像集合，所述时间点集合和所述静止信号来确定单峰运动信号; 基于静止信号去除细胞亚群的单峰运动信号; 确定细胞亚群的一组运动特征的值，从而表征细胞运动; 以及基于所述单峰运动信号和所述运动特征集合的值中的至少一个，将所述细胞亚群与至少一个其它细胞亚群聚集。
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公开(公告)号：US09355459B2
公开(公告)日：2016-05-31
申请号：US14260087
申请日：2014-04-23
申请人： Cellogy, Inc.
CPC分类号： G06T7/0016 , G06K9/0014 , G06K9/6215 , G06T7/20 , G06T7/215 , G06T7/246 , G06T2207/10016 , G06T2207/30004 , G06T2207/30024 , G06T2207/30048
摘要： A method and system for characterizing cell motion comprising: receiving image data corresponding to a set of images of a cell culture captured at a set of time points; segmenting, from at least one image of the set of images, a cell subpopulation from the cell culture; determining a resting signal for the cell subpopulation; determining a single-peak motion signal based upon the set of images, the set of time points, and the resting signal; detrending the single-peak motion signal of the cell subpopulation based upon the resting signal; determining values of a set of motion features of the cell subpopulation, thereby characterizing cell motion; and clustering the cell subpopulation with at least one other cell subpopulation based upon at least one of the single-peak motion signal and a value of the set of motion features.
摘要翻译： 一种用于表征细胞运动的方法和系统，包括：接收与在一组时间点捕获的细胞培养物的一组图像相对应的图像数据; 从所述图像集合中的至少一个图像分割来自所述细胞培养物的细胞亚群; 确定细胞亚群的静息信号; 基于所述图像集合，所述时间点集合和所述静止信号来确定单峰运动信号; 基于静止信号去除细胞亚群的单峰运动信号; 确定细胞亚群的一组运动特征的值，从而表征细胞运动; 以及基于所述单峰运动信号和所述运动特征集合的值中的至少一个，将所述细胞亚群与至少一个其它细胞亚群聚集。
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公开(公告)号：US20150087240A1
公开(公告)日：2015-03-26
申请号：US14492385
申请日：2014-09-22
申请人： Cellogy, Inc.
CPC分类号： G06T7/0012 , G06K9/00147 , G06T7/0016 , G06T7/11 , G06T7/143 , G06T7/60 , G06T2207/20081 , G06T2207/30024
摘要： A method and system for characterizing a cell population including a set of cell subpopulations, the method comprising: at a processing system, receiving image data corresponding to a set of images of the cell population captured at a set of time points; at the processing system, generating an analysis based upon processing the set of images according to: a cell stage classification module configured to automatically identify a cell class of each of the set of cell subpopulations, and a cell graph representation module configured to characterize geometric and spatial features of the set of cell subpopulations; from the analysis, determining a set of parameters characterizing the cell population; and generating an indication of quality of the cell population based upon a comparison between at least one parameter of the set of parameters and a set of reference values.
摘要翻译： 一种用于表征包括一组细胞亚群的细胞群体的方法和系统，所述方法包括：在处理系统处，接收对应于在一组时间点捕获的细胞群体的一组图像的图像数据; 在所述处理系统处，基于根据以下处理所述图像集合来生成分析：细胞级分类模块，被配置为自动识别所述一组细胞亚群中的每一个的细胞类别，以及细胞图表示模块，其被配置为表征几何和 一组细胞亚群的空间特征; 从分析中确定表征细胞群体的一组参数; 以及基于所述一组参数中的至少一个参数和一组参考值之间的比较来生成所述小区群体的质量的指示。
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公开(公告)号：US20160239970A1
公开(公告)日：2016-08-18
申请号：US15140745
申请日：2016-04-28
申请人： Cellogy, Inc.
CPC分类号： G06T7/0016 , G06K9/0014 , G06K9/6215 , G06T7/20 , G06T7/215 , G06T7/246 , G06T2207/10016 , G06T2207/30004 , G06T2207/30024 , G06T2207/30048
摘要： A method and system for characterizing cell motion comprising: receiving image data corresponding to a set of images of a cell culture captured at a set of time points; segmenting, from at least one image of the set of images, a cell subpopulation from the cell culture; determining a resting signal for the cell subpopulation; determining a single-peak motion signal based upon the set of images, the set of time points, and the resting signal; detrending the single-peak motion signal of the cell subpopulation based upon the resting signal; determining values of a set of motion features of the cell subpopulation, thereby characterizing cell motion; and clustering the cell subpopulation with at least one other cell subpopulation based upon at least one of the single-peak motion signal and a value of the set of motion features.
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公开(公告)号：US20150213614A1
公开(公告)日：2015-07-30
申请号：US14260087
申请日：2014-04-23
申请人： Cellogy, Inc.
CPC分类号： G06T7/0016 , G06K9/0014 , G06K9/6215 , G06T7/20 , G06T7/215 , G06T7/246 , G06T2207/10016 , G06T2207/30004 , G06T2207/30024 , G06T2207/30048
摘要： A method and system for characterizing cell motion comprising: receiving image data corresponding to a set of images of a cell culture captured at a set of time points; segmenting, from at least one image of the set of images, a cell subpopulation from the cell culture; determining a resting signal for the cell subpopulation; determining a single-peak motion signal based upon the set of images, the set of time points, and the resting signal; detrending the single-peak motion signal of the cell subpopulation based upon the resting signal; determining values of a set of motion features of the cell subpopulation, thereby characterizing cell motion; and clustering the cell subpopulation with at least one other cell subpopulation based upon at least one of the single-peak motion signal and a value of the set of motion features.
摘要翻译： 一种用于表征细胞运动的方法和系统，包括：接收与在一组时间点捕获的细胞培养物的一组图像相对应的图像数据; 从所述图像集合中的至少一个图像分割来自所述细胞培养物的细胞亚群; 确定细胞亚群的静息信号; 基于所述图像集合，所述时间点集合和所述静止信号来确定单峰运动信号; 基于静止信号去除细胞亚群的单峰运动信号; 确定细胞亚群的一组运动特征的值，从而表征细胞运动; 以及基于所述单峰运动信号和所述运动特征集合的值中的至少一个，将所述细胞亚群与至少一个其它细胞亚群聚集。
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