公开(公告)号：US20170073755A1

公开(公告)日：2017-03-16

申请号：US15122101

申请日：2015-02-27

Applicant: Centre For Addiction and Mental Health

Inventor： Arun K Tiwari ,  Eva J. Brand ,  Nabilah I. Chowdhury ,  Vanessa F. Gonçalves ,  Jennie G. Pouget ,  James L. Kennedy ,  Daniel J. Mueller ,  Clement C. Zai

IPC: C12Q1/68 ,  A61K31/519 ,  G06F19/18 ,  A61K31/445

Abstract: The invention provides methods and compositions for the treatment of a subject having a psychiatric disease or dis order based upon the subject's genotype and/or the number of risk alleles carried by the subject, which risk alleles have been found by the present inventors to predispose a subject to antipsychotic medication induced weight gain (AIWG). The methods of the inven tion also provide for different treatments, or different treatment regimens, for the subject depending on the subject's risk of AIWG. Related compositions, in the form of kits, systems, and computer-readable media are also provided.

Abstract translation: 本发明提供了用于治疗患有基于受试者的基因型和/或受试者携带的风险等位基因数目的精神疾病或疾病顺序的受试者的方法和组合物，本发明人发现风险等位基因易于使用 服用抗精神病药物引起的体重增加（AIWG）。 本方法还根据受试者的AIWG风险，为受试者提供不同的治疗方案或不同的治疗方案。 还提供了试剂盒，系统和计算机可读介质形式的相关组合物。