公开(公告)号：US20200270339A1

公开(公告)日：2020-08-27

申请号：US16471616

申请日：2017-12-21

Applicant: Cephalon, Inc.

Inventor： David Jose Simon LAINE ,  Matthew POLLARD ,  Anthony Gerard DOYLE ,  Lynn Dorothy POULTON ,  Adam William CLARKE

IPC: C07K16/24 ,  A61P1/00 ,  A61P3/00 ,  A61P37/00 ,  A61P29/02

Abstract: Recombinant antibodies that specifically bind to IL-15 as well as a complex of IL-15 and the IL-15 Receptor-alpha are provided. The antibodies inhibit immune cell proliferation, and are capable of use in the treatment of any autoimmune or inflammatory disease or condition where IL-15 is dysregulated, including Celiac disease.

公开(公告)号：US20220127352A1

公开(公告)日：2022-04-28

申请号：US17647082

申请日：2022-01-05

Applicant: Cephalon, Inc.

Inventor： David Jose Simon LAINE ,  Matthew POLLARD ,  Anthony Gerard DOYLE ,  Lynn Dorothy POULTON ,  Adam William CLARKE

IPC: C07K16/24 ,  A61P37/00 ,  A61P3/00 ,  A61P29/02 ,  A61P1/00

Abstract: Recombinant antibodies that specifically bind to IL-15 as well as a complex of IL-15 and the IL-15 Receptor-alpha are provided. The antibodies inhibit immune cell proliferation, and are capable of use in the treatment of any autoimmune or inflammatory disease or condition where IL-15 is dysregulated, including Celiac disease.