公开(公告)号：US20240301076A1

公开(公告)日：2024-09-12

申请号：US18666190

申请日：2024-05-16

Applicant: Cephalon LLC

Inventor： Doris Shim Siew Chen ,  Lynn Dorothy Poulton ,  Adam Clarke ,  David Jose Simon Laine ,  Matthew Pollard ,  Bridget Ann Cooksey ,  Anthony Doyle ,  Jason William Gill

IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395 ,  A61P11/00 ,  G01N33/53

CPC classification number: C07K16/2866 ,  A61P11/00 ,  A61K39/395 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/53

Abstract: Disclosed herein are human antibody molecules that immunospecifically bind to human CXCR2. The disclosed human antibody molecules are potent and selective antagonists of CXCR2 functions and prevent the recruitment of neutrophils into tissues without strongly depleting circulating neutrophil numbers. Pharmaceutical compositions, nucleic acid molecules, vectors, cells, and uses of the disclosed antibodies are also provided.

公开(公告)号：US12018084B2

公开(公告)日：2024-06-25

申请号：US17718622

申请日：2022-04-12

Applicant: Cephalon LLC

Inventor： Doris Shim Siew Chen ,  Lynn Dorothy Poulton ,  Adam Clarke ,  David Jose Simon Laine ,  Matthew Pollard ,  Bridget Ann Cooksey ,  Anthony Doyle ,  Jason William Gill

IPC: A61K39/395 ,  A61P11/00 ,  C07K16/28 ,  G01N33/53 ,  A61K39/00

CPC classification number: C07K16/2866 ,  A61P11/00 ,  A61K39/395 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/53

Abstract: Disclosed herein are human antibody molecules that immunospecifically bind to human CXCR2. The disclosed human antibody molecules are potent and selective antagonists of CXCR2 functions and prevent the recruitment of neutrophils into tissues without strongly depleting circulating neutrophil numbers. Pharmaceutical compositions, nucleic acid molecules, vectors, cells, and uses of the disclosed antibodies are also provided.