公开(公告)号：US20100294952A1

公开(公告)日：2010-11-25

申请号：US12687595

申请日：2010-01-14

申请人： Chad A. Mirkin ,  Matthew R. Jones ,  Jill E. Millstone ,  David A. Giljohann ,  Dwight S. Seferos ,  Kaylie L. Young

发明人： Chad A. Mirkin ,  Matthew R. Jones ,  Jill E. Millstone ,  David A. Giljohann ,  Dwight S. Seferos ,  Kaylie L. Young

IPC分类号： A61N5/06

CPC分类号： A61N5/062 ,  A61N2005/0659

摘要： Disclosed are nanostructures having nanoprisms and agents, such as diagnostic and/or therapeutic agents. Nanoprisms with a surface plasmon resonance in the near-infrared convert irradiation, such as from a laser into heat selectively to allow the dissociation, such as dehybridization of oligonucleotide duplexes, of agents associated with the nanoprism surface. These nanostructures show morphological, chemical, and functional stability under hours of irradiation. Further disclosed are methods of selectively releasing agents from nanostructures after directed surface plasmon resonance mediated heating of the nanoprisms. Released agents, such as oligonucleotides, are unharmed by this process and can be repeatedly released and sequestered under spatiotemporal control.

摘要翻译： 公开了具有纳米棱镜和试剂的纳米结构，例如诊断和/或治疗剂。 在近红外转换照射中具有表面等离子体共振的纳米棱镜，例如从激光选择性地加热以允许与纳米棱镜表面相关的试剂的解离，例如寡核苷酸双链体的脱杂交。 这些纳米结构在照射几小时内显示形态，化学和功能稳定性。 进一步公开的是在定向表面等离子体共振介导的纳米棱镜加热之后从纳米结构中选择性释放试剂的方法。 释放的试剂，如寡核苷酸，不受这个过程的伤害，并且可以在时空控制下重复释放和螯合。