公开(公告)号：US20170258940A1

公开(公告)日：2017-09-14

申请号：US15602985

申请日：2017-05-23

申请人： Chad Dickey ,  Bo Zhang ,  Laura Jenelle Blair

发明人： Chad Dickey ,  Bo Zhang ,  Laura Jenelle Blair

IPC分类号： A61K49/00 ,  A01K67/027 ,  C12N15/85 ,  C12N9/90

CPC分类号： A61K49/0006 ,  A01K67/0278 ,  A01K2217/203 ,  A01K2227/105 ,  A01K2267/01 ,  A01K2267/0356 ,  A61K49/0008 ,  C12N9/90 ,  C12N15/8509

摘要： The subject invention pertains to transgenic non-human animals comprising a transgenic nucleotide sequence, integrated into the genome of the animals, comprising a nucleotide sequence encoding human FKBP51 operably linked to a tetracycline response element. In some embodiments, the transgenic animal comprises an additional transgenic nucleotide sequence, integrated into the genome of the animal, comprising a nucleotide sequence encoding a tetracycline transactivator (tTA) operably linked to a promoter; wherein the tTA is expressed upon activation of the promoter and binds the tetracycline response element, thereby causing expression of FKBP51. The invention also pertains to methods for screening for agents for the prevention and/or treatment of psychiatric disorders, such as depression.